| Yazarlar |
Senem Ceren Özen Karataylı
Ankara Üniversitesi, Türkiye |
|
Ülkü Dağlı
Başkent Üniversitesi, Türkiye |
|
Kılıç Mesut Yalın
|
|
Murat Törüner
Ankara Üniversitesi, Türkiye |
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU
Kastamonu Üniversitesi, Türkiye |
|
Mustafa Muhip Özkan
Ankara Üniversitesi, Türkiye |
|
Arif İrfan Soykan
Ankara Üniversitesi, Türkiye |
|
Hülya Çetinkaya
Ankara Üniversitesi, Türkiye |
|
Aysel Ülker
|
|
Ali Özden
|
|
Abdurrahman Mithat Bozdayı
Ankara Üniversitesi, Türkiye |
| Özet |
| Purpose: The genetic susceptibility of people with certain NOD2/CARD15, NOD1/CARD4, and ICAM-1 gene variants to inflammatory bowel disease is still under investigation. The aim of this study was to investigate polymorphisms in the NOD2/CARD15 (R702W, G908R, and 3020insC), NOD1/ CARD4 (E266K, D372N), and ICAM-1 (G241R, K469E) genes, which are known to be associated with inflammation, in Turkish patients with inflammatory bowel disease and healthy control groups. Methods: The genotypes of 70 patients with endoscopically and histopathologically diagnosed Crohn's disease (38 men, 32 women; mean age, 38.8 ± 1.3), 120 patients with ulcerative colitis (67 men, 53 women; mean age, 41.7 ±1.3) and 106 healthy control subjects (37 men, 69 women; mean age, 35.7 ± 1.4), who stated that they had never had any prior bowel disease history, were compared. A polymerase chain reaction-restriction fragment length polymorphism analysis was performed for two variants of the ICAM-1 gene, the three main variants of the NOD2/CARD15 gene, and the E266K variant of the NOD1/ CARD4 gene, and DNA sequencing was used for the D372N polymorphism of the NOD1/CARD4 gene. Results: In this study, the three previously described Crohn's disease-predisposing variants of the NOD2/CARD15 gene and the polymorphisms examined in the NOD1/CARD4 and ICAM-1 genes were not found to be associated with ulcerative colitis or Crohn's disease. Conclusions: These findings suggest that the polymorphisms observed in the NOD2/CARD15, NOD1/CARD4, and ICAM-1 genes are not genetic susceptibility factors for Crohn's disease or ulcerative colitis in Turkey. © Springer-Verlag 2006. |
| Anahtar Kelimeler |
| Crohn's disease | ICAM | Inflammatory bowel disease | NOD/CARD | Ulcerative colitis |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | J Gastroenterol |
| Dergi ISSN | 0944-1174 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2006 |
| Cilt No | 41 |
| Sayı | 4 |
| Sayfalar | 304 / 310 |
| Doi Numarası | 10.1007/s00535-005-1780-z |
| Atıf Sayıları | |
| SCOPUS | 53 |
| Google Scholar | 73 |
