Effect of lipoic acid on cisplatin-induced cardiotoxicity and inflammation in cardiomyocytes
Yazarlar (3)
Doç. Dr. Yener YAZĞAN Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ramazan Çınar Bilecik Şeyh Edebali Üniversitesi, Türkiye
Dr. Öğr. Üyesi Betül YAZĞAN Kastamonu Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(Diğer hakemli uluslarası dergilerde yayınlanan tam makale)
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| Dergi Adı | Kastamonu Medical Journal | ||
| Dergi ISSN | 2757-9336 | ||
| Dergi Tarandığı Indeksler | TR DİZİN | ||
| Makale Dili | Türkçe | Basım Tarihi | 12-2024 |
| Cilt / Sayı / Sayfa | 4 / 4 / 175–181 | DOI | 10.51271/KMJ-0167 |
| Makale Linki | https://doi.org/10.51271/kmj-0167 | ||
| UAK Araştırma Alanları |
Fizyoloji
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| Özet |
| Aims Cisplatin (CPL) is a potent chemotherapeutic agent widely used to treat various cancers. However, CPL causes toxicity in various tissues, including the heart. Lipoic acid (LPA) is a thiol compound with antioxidant, anti-inflammatory, and antiapoptotic properties. Although LPA has been reported to have protective effects in various cardiac diseases, the mechanisms underlying its cardio-protective effects have not been elucidated. This study aimed to establish a CPL-induced cardiotoxicity model in the H9c2 cardiomyocyte cell line, to understand the mechanisms underlying this cardiotoxicity, and to investigate the effect of LPA on cardiotoxicity.Methods H9c2 cardiomyocyte cells as control (CNT), CPL (40 μm), and LPA-1 (300 μm LPA, and 40 μm CPL), LPA-2 (500 μm LPA, and 40 μm CPL) in combination along with CIS were used. In the analyses made, glutathione (GSH) and glutathione peroxidase (GSHPx) enzyme activity, lipid peroxidation [malondialdehyde,(MDA)] levels, inflammation markers interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α levels, total oxidant/antioxidant (TOS and TAS) status levels, reactive oxygen species (ROS) and caspase activity (Casp 3 and 9) in the cells were determined. Results CIS treatment caused cardiomyocyte cell toxicity and increased Casp 3, Casp 9, ROS, IL-1β, IL-6, TNF-α, TOS, and MDA levels while decreasing GSHPx, GSH, and TAS levels. Increased inflammation and impaired oxidant/antioxidant balance in cardiomyocyte cells after CPL treatment were regulated by LPA treatment. Conclusion LPA treatment was found to have a protective effect against CPL-induced cardiotoxicity in ... |
| Anahtar Kelimeler |
| Apoptosis | lipoic acid | cardiotoxicity | cisplatin | oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
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