Molecular Docking Application for the Potential use of Palmitic Acid as an AcrB, an Efflux Pump Protein, Inhibitor
Yazarlar (3)
Eda Altınöz
Prof. Dr. Ilgaz Akata Ankara Üniversitesi, Türkiye
Prof. Dr. Ergin Murat ALTUNER Kastamonu Üniversitesi, Türkiye
| Bildiri Türü |
Tebliğ/Bildiri
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Bildiri Dili | İngilizce |
| Bildiri Alt Türü | Tam Metin Olarak Yayınlanan Tebliğ (Uluslararası Kongre/Sempozyum) | ||
| Bildiri Niteliği | Alanında Hakemli Uluslararası Kongre/Sempozyum | ||
| Kongre Adı | Horizons of Innovation: Conference on Multidisciplinary Trends in Science 2024 | ||
| Kongre Tarihi | 28-02-2024 / 01-03-2024 | ||
| Basıldığı Ülke | Polonya | Basıldığı Şehir | |
| UAK Araştırma Alanları |
Biyokimya
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| Özet |
| Studies continue every day with the increase in multi-drug resistance in bacteria. In this study, the effect of potential inhibitors against the efflux pump with natural components in extracts obtained from some macrofungus to increase the effectiveness of antibiotics was investigated with an in silico study. Molecular docking was performed on the inhibition effect of palmitic acid against the AcrB (4DX5) protein of the RND pump. As a result of the modelling, it was determined that it had an inhibitory effect, and the binding affinity was-2.14 kcal mol-1. Although palmitic acid may be a promising RND efflux pump inhibitor against multi-drug resistance Escherichia coli, further supportive studies are required. |
| Anahtar Kelimeler |