Altered luteal expression patterns of genomic and non-genomic progesterone receptors in bitches at different reproductive states
Yazarlar (7)
Mustafa Hitit
Kastamonu Üniversitesi, Türkiye
Doç. Dr. Musa TATAR Kastamonu Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Theriogenology (Q1)
Dergi ISSN 0093-691X Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili Türkçe Basım Tarihi 04-2024
Cilt / Sayı / Sayfa 218 / 0 / 153–162 DOI 10.1016/j.theriogenology.2024.02.001
Makale Linki https://doi.org/10.1016/j.theriogenology.2024.02.001
Özet
The binding of steroid hormones to their specific receptors is necessary to exert their effects on target cells. Progesterone (P4), a steroid hormone, carries out its effects through both genomic and non-genomic (the cell membrane-associated) receptors. This study aimed to ascertain luteal expression patterns of genomic and non-genomic progesterone receptors in bitches in physiological (early dioestrus and early pregnant) and pathological (pyometra) reproductive states. Luteal tissue was collected from the bitches at early dioestrus (ED, n = 5), early pregnant (EP, n = 5), and pyometra (PY, n = 5). The expression profiles of Steroidogenic Acute Regulator Protein (STAR), Progesterone Receptor (PGR), Membrane Progestin Receptors (PAQR5, PAQR7 and PAQR8), and Progesterone Membrane Components (PGMRC1 and PGMRC2) were examined at the mRNA levels using Real-Time Polymerase Chain Reaction …
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