Exploring the anti‑inflammatory activity of boron compounds through the miR‑21/PTEN/AKT pathway in cecal ligation and puncture‑induced sepsis
Yazarlar (12)
Doç. Dr. Çiğdem SEVİM Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mustafa Özkaraca Sivas Cumhuriyet Üniversitesi, Türkiye
Doç. Dr. Mehtap Kara İstanbul Üniversitesi, Türkiye
Doç. Dr. Alı Taghızadehghalehjoughı Bilecik Şeyh Edebali Üniversitesi, Türkiye
Doç. Dr. Sıdıka Genç Bilecik Şeyh Edebali Üniversitesi, Türkiye
Dr. Öğr. Üyesi Yeşim Yeni Malatya Turgut Özal Üniversitesi, Türkiye
Ali Sefa Mendil
Erciyes Üniversitesi, Türkiye
Erciyes Üniversitesi, Türkiye
Marios Spanakis
University of Crete, Yunanistan
University of Crete, Yunanistan
Eren Özçağlı
İstanbul Üniversitesi, Türkiye
İstanbul Üniversitesi, Türkiye
Sergey V. Kuzmin
Federal Scientific Center For Hygiene Named After F.F. Erisman, Rusya Federasyonu
Federal Scientific Center For Hygiene Named After F.F. Erisman, Rusya Federasyonu
Demetrios A. Spandidos
University of Crete, Yunanistan
University of Crete, Yunanistan
Aristides Tsatsakis
University of Crete, Yunanistan
University of Crete, Yunanistan
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Molecular Medicine Reports (Q2) | ||
| Dergi ISSN | 1791-2997 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2025 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 13-12-2024 |
| Cilt / Sayı / Sayfa | 31 / 2 / 1–14 | DOI | 10.3892/mmr.2024.13417 |
| Makale Linki | https://doi.org/10.3892/mmr.2024.13417 | ||
| UAK Araştırma Alanları |
Tıbbi Farmakoloji
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| Özet |
| The present study investigated the impact of boric acid (BA) and borax (BX) on markers of inflammation and modifications in miR-21/PTEN/AKT pathway genes in the liver and kidney tissues of Sprague Dawley male rats with sepsis induced by cecal ligation and puncture (CLP). A total of 60 male Sprague Dawley rats were randomly divided into 6 groups, each containing 10 animals as follows: Control, CLP (where the model was created), 20 mg/kg BX (CLP + BX1), 40 mg/kg BX (CLP + BX2), 20 mg/kg BA (CLP + BA1) and 40 mg/kg BA (CLP + BA2). Liver and kidney tissues were analyzed for histopathological changes, immunopositivity for tumor necrosis factor-α, interleukin (IL)-6 and IL-10, and gene expression of microRNA-21 (miR-21), phosphatase and tensin homolog (PTEN) and AKT. Gene expression analysis in the liver tissues revealed a significant decrease in miR-21, and a marked but not significant … |
| Anahtar Kelimeler |
| borax | boric acid | CLP-model | cytokine | sepsis | septic shock |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 6 |
| Scopus | 7 |
| Google Scholar | 9 |