Albumin-based nanocarriers loaded with novel Zn(II)-thiosemicarbazone compounds chart a new path for precision breast cancer therapy
Yazarlar (6)
Ferdane Danişman-Kalindemirtaş
Erzincan Binali Yıldırım Üniversitesi, Türkiye
Erzincan Binali Yıldırım Üniversitesi, Türkiye
Doç. Dr. Dilşad ÖZERKAN Kastamonu Üniversitesi, Türkiye
Prof. Dr. Ishak Afşin Kariper Erciyes Üniversitesi, Türkiye
Dr. Öğr. Üyesi Gökçe Erdemir Cilasun Biruni Üniversitesi, Türkiye
Bahri Ülküseven
Istanbul University-Cerrahpasa, Türkiye
Istanbul University-Cerrahpasa, Türkiye
Serap Erdem-Kuruca İstanbul Atlas Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Anti Cancer Drugs (Q3) | ||
| Dergi ISSN | 0959-4973 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 01-2025 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 06-01-2025 |
| Cilt / Sayı / Sayfa | 36 / 3 / 208–219 | DOI | 10.1097/CAD.0000000000001679 |
| Makale Linki | https://doi.org/10.1097/cad.0000000000001679 | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
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| Özet |
| This study explores the therapeutic potential of albumin-bound Zn (II)-thiosemicarbazone compounds (Alb-ZnTcA, Alb-ZnTcB) against breast cancer cells. Previous research indicates that these compounds hinder cancer cell proliferation by blocking DNA synthesis, promoting oxidative stress to induce apoptosis, and disrupting the cell cycle to inhibit cellular division. This study focuses on the loading and characterization of these potentially chemically unstable compounds on bovine serum albumin-based nanocarriers. Accordingly, unlike previous studies using albumin nanoparticles, in this study, ultraviolet light was used to precisely bind the therapeutic agent to albumin during the integration of thiosemicarbazones, achieving controlled nanoparticle size to control nanoparticle size. The mean diameter of Alb-ZnTcA nanoparticles was 32 nm, while Alb-ZnTcB exhibited an average diameter of 43 nm. Notably, Alb … |
| Anahtar Kelimeler |
| breast cancer treatment | nanoparticles | research & development | thiosemicarbazone-bovine serum albumin | thiosemicarbazones | zinc |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 3 |
| Scopus | 3 |
| Google Scholar | 4 |