Valdecoxib Recovers the Lipid Composition Order and Dynamics in Colon Cancer Cell Lines Independent of COX 2 Expression An ATR FTIR Spectroscopy Study
Yazarlar (4)
Arş. Gör. Dr. Aysun İNAN GENÇ Kastamonu Üniversitesi, Türkiye
Seher Gök Bilecik Şeyh Edebali Üniversitesi, Türkiye
Sreeparna Banerjee Orta Doğu Teknik Üniversitesi, Türkiye
Feride Severcan İstanbul Kemerburgaz Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Applied Spectroscopy (Q1) | ||
| Dergi ISSN | 0003-7028 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2017 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 20-07-2016 |
| Cilt / Sayı / Sayfa | 71 / 1 / 105–117 | DOI | 10.1177/0003702816654164 |
| Makale Linki | http://asp.sagepub.com/lookup/doi/10.1177/0003702816654164 | ||
| Özet |
| Prostanoids play an important role in a variety of physiological and pathophysiological processes including inflammation and cancer. The rate-limiting step in the prostanoid biosynthesis pathway is catalyzed by cyclooxygenases (COXs). Aberrant expression of the inducible isoform COX-2 plays a significant role in colon cancer initiation and progression. In this study, we have hypothesized that COX-2 specific inhibitors such as Valdecoxib (VLX), being highly hydrophobic, may alter biophysical properties of cellular lipids. In this study, COX-2 expressing (HT29) and COX-2 non-expressing (SW620) colon cancer cell lines were treated with VLX and examined using attenuated total reflection infrared spectroscopy. The results revealed that VLX treatment decreased lipid fluidity in the cells irrespective of COX-2 expression status and affected order parameters of the lipids in both cell lines. Cluster analysis also indicated … |
| Anahtar Kelimeler |
| ATR-FT-IR spectroscopy | attenuated total reflection infrared spectroscopy | Colon cancer | COX-2 inhibitors | HT29 | SW620 | valdecoxib |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 14 |
| Scopus | 18 |
| Google Scholar | 26 |