A determination of the main regulators of necroptosis in testicular tissue under different heat stresses
Yazarlar (3)
Doç. Dr. Musa TATAR Kastamonu Üniversitesi, Türkiye
Doç. Dr. Kıymet Kübra TÜFEKCİ Kastamonu Üniversitesi, Türkiye
Sema Uslu Sivas Cumhuriyet Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Molecular Histology (Q4) | ||
| Dergi ISSN | 1567-2379 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2025 |
| Cilt / Sayı / Sayfa | 56 / 74 / 1–12 | DOI | 10.1007/s10735-024-10350-x |
| Makale Linki | https://doi.org/10.1007/s10735-024-10350-x | ||
| UAK Araştırma Alanları |
Veteriner Histoloji ve Embriyolojisi
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| Özet |
| Although minimal increases in testicular temperature can compromise spermatogenesis and lead to fertility-related problems, the basic mechanism involved in germ cell destruction as a response to heat stress is still unclear. However, necroptosis is known to regulate a number of physiological and pathological events. This study investigated the role of RIPK1/RIPK3 and MLKL, the main regulators of necroptosis, against different heat stresses in testis tissue. Forty-two Wistar albino rats were divided into seven groups: six experimental exposed to heat stress and one control. Heat stress was induced by causing the rats to swim for 30 min daily for 60 days in a water bath at temperatures of 39 °C and 43 °C. Testis tissues were collected while the animals were under anesthesia on the 1st, 7th, and 14th days after 60 days of heat application. The tissues were first fixed in Bouin’s solution. After routine histological … |
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| Google Scholar | 3 |