Anti-atrophic role of Ononis natrix subsp. hispanica extract in skeletal muscle atrophy: Pathway-targeted insights and experimental validation
Yazarlar (5)
Doç. Dr. Uğur AKPULAT Kastamonu Üniversitesi, Türkiye
Mehmet Veysi Çetiz Harran University, Faculty Of Medicine, Türkiye
Prof. Dr. Mehmet Cengiz BALOĞLU Kastamonu Üniversitesi, Türkiye
Prof. Dr. Yasemin ÇELİK ALTUNOĞLU Kastamonu Üniversitesi, Türkiye
Prof. Dr. Gökhan Zengin Selçuk Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Food Bioscience (Q1) | ||
| Dergi ISSN | 2212-4292 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2025 |
| Cilt / Sayı / Sayfa | 64 / 1 / 106000–0 | DOI | 10.1016/j.fbio.2025.106000 |
| Makale Linki | https://doi.org/10.1016/j.fbio.2025.106000 | ||
| Özet |
| Skeletal muscle atrophy, a condition associated with sarcopenia, cachexia, and various metabolic diseases, significantly impairs physical function and quality of life. This study investigates the potential of Ononis natrix subsp. hispanica water extract, rich in quercetin, luteolin, and apigenin, to mitigate muscle atrophy in an in vitro model. Atrophy was induced in differentiated C2C12 myotubes using dexamethasone, and the effects of the extract and a mixture of its phytochemicals (QLA mixture) were evaluated on myotube morphology and key protein degradation markers. The extract significantly reduced dexamethasone-induced myotube diameter loss from 28% to 13%–15.4% (p < 0.001). Similarly, the QLA mixture limited diameter loss to 14.6%, maintaining a morphology closer to the control. The extract and QLA mixture attenuated the dexamethasone-induced upregulation of muscle-specific ubiquitin ligases … |
| Anahtar Kelimeler |
| Apigenin | Luteolin | Molecular docking | Ononis natrix | Quercetin | Skeletal muscle atrophy |
Science Direct
Anti-atrophic role of Ononis natrix subsp. hispanica extract in skeletal muscle atrophy: Pathway-targeted insights and experimental validation
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 6 |
| Scopus | 6 |
| Google Scholar | 6 |