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Optical Coherence Tomography-Guided Early Versus Late Switching to Dexamethasone Implants in Macular Edema Related to Central Retinal Vein Occlusion: Real-World Evidence       
Yazarlar (1)
Dr. Öğr. Üyesi Zübeyir YOZGAT Dr. Öğr. Üyesi Zübeyir YOZGAT
Kastamonu Üniversitesi, Türkiye
Devamını Göster
Özet
This study evaluated the outcomes of early versus late switching from intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy to dexamethasone (DEX) implants in patients with macular edema secondary to central retinal vein occlusion (CRVO). The critical role of optical coherence tomography (OCT) in guiding therapeutic decisions and monitoring treatment responses is emphasized. In this real-world, retrospective study, 61 treatment-naïve CRVO patients were divided into two groups: Group 1 (early switch after three anti-VEGF injections) and Group 2 (late switch after six months of anti-VEGF therapy). High-resolution OCT was employed at all follow-ups to evaluate anatomical outcomes, specifically changes in central macular subfield thickness (CMST), while best-corrected visual acuity (BCVA) was assessed using standardized ETDRS charts. Both groups demonstrated significant improvements in BCVA and reductions in CMST over 52 weeks. Group 1 exhibited slightly greater gains in BCVA (+20.3 ETDRS letters) and a greater CMST reduction (-201.5 µm) compared to Group 2 (+18.5 ETDRS letters, -184.4 µm), although the differences were not statistically significant. The OCT findings enabled precise monitoring and individualized treatment adjustments, reducing the treatment burden in the early-switch group with fewer anti-VEGF injections. Early switching to DEX implants, guided by OCT findings, may optimize therapeutic outcomes and reduce the treatment burden, particularly in real-world settings with limited resources or adherence challenges. These findings highlight the importance of incorporating advanced imaging techniques into routine practice, and underscore the need for further research on OCT-guided therapeutic transitions in macular edema management.
Anahtar Kelimeler
anti-VEGF therapy | central retinal vein occlusion | dexamethasone implant | macular edema | optical coherence tomography | real-world study
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Diagnostics
Dergi ISSN 2075-4418 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q1
Makale Dili İngilizce
Basım Tarihi 02-2025
Cilt No 15
Sayı 4
Sayfalar 439 / 0
Doi Numarası 10.3390/diagnostics15040439
Makale Linki https://doi.org/10.3390/diagnostics15040439