Optical Coherence Tomography-Guided Early Versus Late Switching to Dexamethasone Implants in Macular Edema Related to Central Retinal Vein Occlusion: Real-World Evidence
Yazarlar (1)
Doç. Dr. Zübeyir YOZGAT Kastamonu Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Diagnostics (Q1) | ||
| Dergi ISSN | 2075-4418 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2025 |
| Cilt / Sayı / Sayfa | 15 / 4 / 439–0 | DOI | 10.3390/diagnostics15040439 |
| Makale Linki | https://doi.org/10.3390/diagnostics15040439 | ||
| UAK Araştırma Alanları |
Göz Hastalıkları
|
||
| Özet |
| Background/Objectives This study evaluated the outcomes of early versus late switching from intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy to dexamethasone (DEX) implants in patients with macular edema secondary to central retinal vein occlusion (CRVO). The critical role of optical coherence tomography (OCT) in guiding therapeutic decisions and monitoring treatment responses is emphasized. Methods In this real-world, retrospective study, 61 treatment-naïve CRVO patients were divided into two groups: Group 1 (early switch after three anti-VEGF injections) and Group 2 (late switch after six months of anti-VEGF therapy). High-resolution OCT was employed at all follow-ups to evaluate anatomical outcomes, specifically changes in central macular subfield thickness (CMST), while best-corrected visual acuity (BCVA) was assessed using standardized ETDRS charts. Results Both groups demonstrated significant improvements in BCVA and reductions in CMST over 52 weeks. Group 1 exhibited slightly greater gains in BCVA (+20.3 ETDRS letters) and a greater CMST reduction (−201.5 µm) compared to Group 2 (+18.5 ETDRS letters, −184.4 µm), although the differences were not statistically significant. The OCT findings enabled precise monitoring and individualized treatment adjustments, reducing the treatment burden in the early-switch group with fewer anti-VEGF injections. Conclusions Early switching to DEX implants, guided by OCT findings, may optimize therapeutic outcomes and reduce the treatment burden, particularly in real-world settings with limited resources or adherence challenges. These findings … |
| Anahtar Kelimeler |
| anti-VEGF therapy | central retinal vein occlusion | dexamethasone implant | macular edema | optical coherence tomography | real-world study |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 1 |
| Google Scholar | 1 |