Rejuvenating the gut: young plasma therapy improves cell proliferation, IGF-I and IGF-IR expression, and immune defense in aged male rats jejunum
Yazarlar (5)
Ender Deniz Asmaz Ankara Medipol Üniversitesi, Türkiye
Murat Tan Demiroglu Bilim University, Türkiye
Arş. Gör. Dr. Aysun İNAN GENÇ Kastamonu Üniversitesi, Türkiye
Hikmet Taner Teker Ankara Medipol Üniversitesi, Türkiye
Taha Ceylani Muş Alparslan Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
|
||
| Dergi Adı | Biogerontology (Q2) | ||
| Dergi ISSN | 1389-5729 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 02-2025 |
| Cilt / Sayı / Sayfa | 26 / 2 / 62–0 | DOI | 10.1007/s10522-025-10204-3 |
| Makale Linki | https://doi.org/10.1007/s10522-025-10204-3 | ||
| Özet |
| It is well known that aging affects many systems in the body. The digestive system is one of the systems most affected by aging. In our study, we examined the effects of young plasma treatment on cell proliferation, growth factors, immune defense and histological parameters in the jejunum of aged male rats. For this purpose, aged male Sprague Dawley rats (24 months, n = 7) were treated with pooled plasma (0.5 ml/day, intravenously for 30 days) collected from young (5 weeks, n = 51) rats. Aged rats that received young plasma treatment were grouped as the experimental group, while aged rats formed the control group. At the end of the experiment, the jejunums of the groups were collected and histological parameters such as villus height, crypt depth, total mucosal thickness and surface absorption areas were measured and compared. In addition, cell proliferation index and proliferation intensity in the crypt … |
| Anahtar Kelimeler |
| IgA | IGF-I | IGF-IR | Jejunum | Proliferation | Young plasma |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 2 |