Doxorubicin functionalized metallic nanoparticles for anticancer and antibacterial applications
Yazarlar (12)
İrem Yeşil
Kastamonu Üniversitesi, Türkiye
Kastamonu Üniversitesi, Türkiye
Harika Atmaca
Manisa Celâl Bayar Üniversitesi, Türkiye
Manisa Celâl Bayar Üniversitesi, Türkiye
Suna Değirmenci
Kastamonu Üniversitesi, Türkiye
Kastamonu Üniversitesi, Türkiye
Çisil Çamlı-Pulat
Manisa Celâl Bayar Üniversitesi, Türkiye
Manisa Celâl Bayar Üniversitesi, Türkiye
Dr. Öğr. Üyesi Murat Arı Aydin Adnan Menderes University, Türkiye
Dr. Öğr. Üyesi Muammer Tepe Manisa Celâl Bayar Üniversitesi, Türkiye
Ardanur Küçük
Kastamonu Üniversitesi, Türkiye
Kastamonu Üniversitesi, Türkiye
Derya Selcen Salmanoğlu
Ege Üniversitesi, Türkiye
Ege Üniversitesi, Türkiye
Dr. Öğr. Üyesi Zafer SANCAK Kastamonu Üniversitesi, Türkiye
Çetin Kılınç Kastamonu Üniversitesi, Türkiye
Prof. Dr. Suleyman Ilhan Manisa Celâl Bayar Üniversitesi, Türkiye
Prof. Dr. İdris YAZGAN Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Drug Delivery Science and Technology (Q1) | ||
| Dergi ISSN | 1773-2247 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 03-2025 |
| Cilt / Sayı / Sayfa | 105 / 1 / 106653–0 | DOI | 10.1016/j.jddst.2025.106653 |
| Makale Linki | https://doi.org/10.1016/j.jddst.2025.106653 | ||
| Özet |
| In this study, we used Doxorubicin, an FDA approved drug possessing anticancer and antibacterial activity, as a model drug to functionalize sugar ligand synthesized silver/gold bimetallic nanoparticles (Ag/AuNPs) to test simultaneous antibacterial and anticancer activities under in vitro conditions. DU-145 prostate cancer cells were used as the main target while T98G glioblastoma and MDA-MB-231 breast cancer cell lines were used for selectivity test, and HEK-293 epithelial cell line was used as non-cancerous cells to test toxicity of these formulations. Three Ag/AuNP and corresponding Doxorubicin (D) functionalized ones and free Doxorubicin were tested for these four cell lines. Plain Ag/AuNP showed the highest toxicities on HEK-293 cell lines while DU-145 cell line showed the greatest vulnerability for Ag/AuNP-D formulations. However, DU-145 cells showed the lowest susceptibility for free Doxorubicin at all the tested concentrations. The antiproliferative activity was not dose dependent while an inverse relationship was obtained for a certain concentration range. Two Doxorubicin functionalized gold nanoparticles (AuNP-D) were then synthesized and applied on DU-145 cells. Interestingly, a better anticancer activity was obtained even at the minimum applied concentration (1.8 × 10−5 μg/mL D). Antibacterial activities of these formulations were also tested for multidrug-resistant gram (−) and gram (+) bacterial species. Depending on the sugar ligand chemistry, antibacterial activity of Doxorubicin functionalized Ag/AuNPs showed a better performance in comparison to the plain Ag/AuNPs and vice-versa. Based on the results, it can be claimed that selective or semi-selective formulations targeting cancer cells and bacterial species as anti-neutropenia formulations can be developed using carbohydrate derivatives synthesized metallic nanoparticles as drug delivery agents. |
| Anahtar Kelimeler |
| Doxorubicin | Neutropenia | Prostate cancer | Silver/gold bimetallic nanoparticle |
Science Direct
Doxorubicin functionalized metallic nanoparticles for anticancer and antibacterial applications
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Scopus | 3 |