| Yazarlar (1) |
Dr. Öğr. Üyesi Fatemeh MOLLAAMIN
Türkiye |
| Özet |
| Aim: Validation for assay and dissolution of metformin and Empagliflozin in tablet 500:5 mg for evaluating the efficacy and safety of linagliptin vs. placebo in patients with type 2 diabetes. Materials and methods: The HPLC system used was Shimadzu LC-2010 HT with UV detector and Empagliflozin standard stock 1: 28 mg of Empagliflozin was accurately prepared. Separately 10 µL of standard solution and sample solution was injected into the chromatographic system. Patients with inadequate glycaemia control despite stable-dose metformin received open-label Empagliflozin as add-on therapy for several weeks. All patients continued treatment with metformin and Empagliflozin or metformin and Empagliflozin. The primary endpoint was change from baseline. Results: The experiments were significantly exhibited a reducing the problem in patients with type 2 diabetes. In addition, results of docking method confirmed also the effectiveness of Metformin/Empagliflozin tablets to better controlling of diabete-type-2 disease. Conclusions: Empagliflozin in Metformin/Empagliflozin for 24 weeks improved glycaemia control and was well tolerated. |
| Anahtar Kelimeler |
| control de la glucemia | controle da glicemia | design de fármacos | diabetes tipo 2 | diabetes tipo 2 | dinámica molecular | dinâmica molecular | diseño de fármacos | docking simulation | drug design | Empagliflozin | Empagliflozina | empagliflozina | glycaemia control | HPLC | HPLC | HPLC | Metformin | metformina | Metformina | molecular dynamic | simulación de acoplamiento | simulação de encaixe | type 2 diabetes |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SCOPUS dergilerinde yayımlanan tam makale |
| Dergi Adı | Revista Colombiana de Ciencias Quimico-Farmaceuticas (Colombia) |
| Dergi ISSN | 0034-7418 |
| Dergi Tarandığı Indeksler | SCOPUS |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2024 |
| Cilt No | 53 |
| Sayı | 3 |
| Sayfalar | 905 / 929 |
| Doi Numarası | 10.15446/rcciquifa.v53n3.119242 |
| Atıf Sayıları |
