Phage-inspired targeting of antibiotic-loaded polymeric micelles for enhanced therapeutic efficacy against monomicrobial sepsis
Yazarlar (13)
Tülin Özbek Yıldız Teknik Üniversitesi, Türkiye
Hatice Demir Yıldız Teknik Üniversitesi, Türkiye
Arş. Gör. Senanur Dokuz Yıldız Teknik Üniversitesi, Türkiye
Arş. Gör. Semra Taşdurmazlı Yıldız Teknik Üniversitesi, Türkiye
Utku Özbey
Yeditepe University, Türkiye
Yeditepe University, Türkiye
Doç. Dr. Mehmet Özbil Gebze Teknik Üniversitesi, Türkiye
Murat Topuzoğulları Yıldız Teknik Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Murat Karameşe Kafkas Üniversitesi, Türkiye
Selina Aksak Karameşe Kafkas Üniversitesi, Türkiye
Serap Acar Yıldız Teknik Üniversitesi, Türkiye
Ömer Faruk Bayrak Yeditepe University, Türkiye
Prof. Dr. Elif Çadırcı Ataturk University, Faculty Of Medicine, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Journal of Controlled Release (Q1) | ||
| Dergi ISSN | 0168-3659 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2025 |
| Cilt / Sayı / Sayfa | 380 / 1 / 773–786 | DOI | 10.1016/j.jconrel.2025.02.035 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S0168365925001488 | ||
| Özet |
| The rapid increase in bacterial resistance to existing treatments underscores the critical need for novel therapeutic strategies. Here, an innovative approach using targeted nanocarrier systems that mimic phage-bacteria interactions through phage receptor binding protein (Gp45 from the ϕ11 lysogenic phage) or derived peptides (P1, P2, P3, P4, P5), are introduced. These nanodrugs, exhibited receptor-ligand specificity and strong binding affinity, for the first time, were employed for the precise delivery and targeting of antibiotics within living organisms. The actively targeted micelles via two methods were produced; conjugating GP45 to dual antibiotic-loaded PLGA-b-PEG micelles (MiGp45) and the synthesis of peptide-conjugated micelles with dual antibiotic-loaded PLGA-b-PEG-peptide triblock copolymers. The untargeted nano-drug reduced MIC values by 2–10 times for vancomycin and 9–75 times for oxacillin … |
| Anahtar Kelimeler |
| Dual antibiotic-loaded nanodrug | Phage-based targeting | Pneumonia sepsis | S. aureus infection |
Science Direct
Phage-inspired targeting of antibiotic-loaded polymeric micelles for enhanced therapeutic efficacy against monomicrobial sepsis
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 5 |
| Google Scholar | 7 |