Decoding Chemical Profiles, Biological Functions, and Medicinal Properties of Liquidambar orientalis Extracts Through Molecular Modeling and Bioinformatic Methods

BALOĞLU, Mehmet Cengiz; Ozer, Lutfiye Yildiz; Pirci, Buket; ÇELİK ALTUNOĞLU, Yasemin; Soomro, Sanam Iram; Zengin, Gökhan; Çetiz, Mehmet Veysi; Carradori, Simone; Cziáky, Zoltán; Jekő, József

doi:10.1002/fft2.545

Decoding Chemical Profiles, Biological Functions, and Medicinal Properties of Liquidambar orientalis Extracts Through Molecular Modeling and Bioinformatic Methods

Yazarlar (10)

Prof. Dr. Mehmet Cengiz BALOĞLU Kastamonu Üniversitesi, Türkiye

Lutfiye Yildiz Ozer
Hamad Bin Khalifa University, College Of Health And Life Sciences, Katar

Buket Pirci
Kastamonu Üniversitesi, Türkiye

Prof. Dr. Yasemin ÇELİK ALTUNOĞLU Kastamonu Üniversitesi, Türkiye

Sanam Iram Soomro
The Aga Khan University, Pakistan

Prof. Dr. Gökhan Zengin Selçuk Üniversitesi, Türkiye

Mehmet Veysi Çetiz
Selçuk Üniversitesi, Türkiye

Simone Carradori University Of G. D'annunzio Chieti And Pescara, İtalya

Zoltán Cziáky University Of Nyíregyháza, Macaristan

József Jekő University Of Nyíregyháza, Macaristan

Makale Türü	Özgün Makale (ESCI dergilerinde yayınlanan tam makale)
Dergi Adı	Food Frontiers
Dergi ISSN	2643-8429 Dergi Bilgileri (2025)
Dergi Tarandığı Indeksler	ESCI
Makale Dili	Türkçe	Basım Tarihi	02-2025
Cilt / Sayı / Sayfa	6 / 3 / 1376–1408	DOI	10.1002/fft2.545
Makale Linki	https://doi.org/10.1002/fft2.545
UAK Araştırma Alanları	Biyoteknoloji

Özet

ABSTRACTLiquidambar orientalis, the Anatolian sweetgum tree, is a relict and endemic species in Southwestern Turkey, traditionally used for therapeutic purposes. Our study comprehensively evaluated the therapeutic potential of L. orientalis extracts from its aerial parts to maximize bioactive compound extraction using methanol, ethyl acetate, and water as solvents. The methanolic extract exhibited the highest phenolic (73.04 ± 3.94 mg gallic acid equivalent [GAE]/g) and flavonoid content (48.86 ± 0.76 mg rutin equivalent [RE]/g), demonstrating superior antioxidant activity in 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) (256.61 ± 1.70 mg Trolox equivalent [TE]/g), 2,2′‐azinobis‐(3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS) (308.41 ± 3.14 mg TE/g), and cupric ion–reducing antioxidant capacity (CUPRAC) (411.13 ± 8.48 mg TE/g) assays. It also showed significant enzyme inhibition for acetylcholinesterase (4.43 ± 0.09 mg galanthamine equivalent [GALAE]/g), tyrosinase (149.16 ± 1.14 mg kojic acid equivalent [KAE]/g), amylase (0.93 ± 0.02 mmol acarbose equivalent [ACAE]/g), and glucosidase (1.60 ± 0.01 mmol ACAE/g), suggesting potential applications in neurodegenerative disease management, skincare, and diabetes treatment. Furthermore, methanol and water extracts displayed promising antimicrobial activity due to phenolic compounds such as chlorogenic acid and methyl‐3‐O‐caffeoyl quinate. The methanolic extract exhibited potent anticancer effects against lung cancer (A549) cells, with significant reductions in cell viability and induction of autophagy. The aqueous extract showed remarkable efficacy against prostate cancer (PC3) cells, modulating apoptosis markers. Breast cancer cells (MDA‐MB‐231) exhibited differential responses, with ethyl acetate extract promoting apoptosis and water extract–enhancing autophagy. Furthermore, molecular docking and dynamics simulations provided additional evidence supporting the therapeutic potential of key phytochemicals from L. orientalis, particularly afzelin and epigallocatechin, against cancer‐related targets and bacterial enzymes. Overall, this study fills a gap in understanding the enzyme inhibitory and diverse anticancer effects of L. orientalis extracts, highlighting its potential multi‐targeted therapeutic applications, particularly in cancer therapy.

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Atıf Sayıları
Scopus	12
Google Scholar	14

Decoding Chemical Profiles, Biological Functions, and Medicinal Properties of Liquidambar orientalis Extracts Through Molecular Modeling and Bioinformatic Methods

Dergi Adı	Food Frontiers
Kısa Adı	FOOD FRONTIERS
Yayıncı	WILEY
Açık Erişim	Evet
ISSN	2643-8429
E-ISSN	2643-8429
Wos Quartile	Q1
Scopus Quartile	Q1
Tarandığı Indeksler	ESCI , Scopus
WoS Kategoriler	FOOD SCIENCE & TECHNOLOGY
Scopus Kategoriler	FOOD SCIENCE

Decoding Chemical Profiles, Biological Functions, and Medicinal Properties of Liquidambar orientalis Extracts Through Molecular Modeling and Bioinformatic Methods

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