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Simple Executive Function as an endophenotype of autism-ADHD, and differing associations between simple versus complex Executive Functions and autism/ADHD traits      
Yazarlar (14)
Alexandra Hendry
Rachael Bedford
Mary Agyapong
Ali Jannath Begum
Tessel Bazelmans
Dr. Öğr. Üyesi Mutluhan ERSOY Dr. Öğr. Üyesi Mutluhan ERSOY
Kastamonu Üniversitesi, Türkiye
Amy Goodwin
Luke Mason
Nisha Narvekar
Greg Pasco
Mark H Johnson
Emily J Jones
Tony Charman
The Basıs Staars Team
Devamını Göster
Özet
Autism and ADHD are associated with difficulties with Executive Functions (EFs), but the prevalence and nature of these difficulties in early development is not well understood. In this longitudinal study, 107 children with a family history of autism and/or ADHD (FH-autism/ADHD), and 24 children with No-FH-autism/ADHD completed multiple EF tasks (5 at age 2 years, 7 at age 3 years). Parents reported on their child's autism- (Q-CHAT at age 2, SRS-2 at age 3), and ADHD-related traits (CBCL DSM-ADHD scale, both ages). Compared to the No-FH-autism/ADHD group, the FH-autism/ADHD group showed lower scores on simple EFs (involving response inhibition, and holding in mind) at ages 2 and 3. Exploratory analysis linked FH-autism specifically with lower Executive Attention (top-down attentional control) at age 2, and the combination of FH-autism and FH-ADHD with lower Complex EF (involving selectively deploying responses, or updating information) at age 3. Three-year-olds' Simple EF scores were negatively associated with ADHD-related traits. Complex EF scores were negatively associated with autism traits (before correcting for multiple comparisons). Toddlers with a family history of autism and/or ADHD may benefit from interventions to support simple EF development, whilst those already showing autistic traits may benefit from support with more-complex EF skills.
Anahtar Kelimeler
ADHD | Autism | Endophenotype | Executive Function | Preschool | Toddler
Makale Türü Özgün Makale
Makale Alt Türü SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale
Dergi Adı Scientific Reports
Dergi ISSN 1324
Dergi Tarandığı Indeksler SCI-Expanded
Dergi Grubu Q1
Makale Dili Türkçe
Basım Tarihi 02-2025
Cilt No 15
Sayı 1
Sayfalar 1 / 15
Doi Numarası 10.1038/s41598-025-87863-2
Makale Linki https://doi.org/10.1038/s41598-025-87863-2