Effect of serotonin 7 receptors and transcript variants on RIN-5F pancreatic beta cell line
Yazarlar (6)
Muhammed Yayla Selçuk Tip Fakültesi, Türkiye
Erdem Toktay Kafkas Üniversitesi, Türkiye
Bengül Özdemir Sarıkaya Kafkas Üniversitesi, Türkiye
Uğur Ermiş Kafkas Üniversitesi, Türkiye
Şakir Akgün Kafkas Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Toxicology in Vitro (Q3) | ||
| Dergi ISSN | 0887-2333 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2025 |
| Cilt / Sayı / Sayfa | 106 / 1 / 11–0 | DOI | 10.1016/j.tiv.2025.106050 |
| Makale Linki | https://www.sciencedirect.com/science/article/pii/S088723332500044X | ||
| Özet |
| PurposeThe physiological effects of 5-HT7 receptors expressed in pancreatic beta cells have not yet been elucidated. We first aimed to investigate the effect of 5-HT7 receptor agonist (AS19) and antagonist (SB269970) application on insulin secretion in RIN-5F pancreatic beta cells. Subsequently, we aimed to investigate the effects of agonist and antagonist applications on cell damage induced by STZ.Materials/MethodsCell damage was caused by giving 5 mM STZ solution to the cells for 12 h. The protective effects of 5-HT7 receptor agonist and antagonist on this subsequent damage were investigated. IGF-1, TNF-α, TGF-B1, NF-KB, Bax, Caspase 3, Caspase 9, 5-HT7, 5HT7x2, 5HT7x3 mRNA expression levels were compared between groups.ResultsWhile agonist application stimulates insulin secretion, the effect of the antagonist varies.SB269970 reduced oxidative stress and downregulated TNF-a, TGF-B1 and … |
| Anahtar Kelimeler |
| 5-HT7 | AS19 | Insulin | RIN-5F | SB269970 |
Science Direct
Effect of serotonin 7 receptors and transcript variants on RIN-5F pancreatic beta cell line
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |