| Yazarlar (5) |
Mehmet Guvenc
|
|
Tuba Aydin
|
|
Tuncer Kutlu
|
Dr. Öğr. Üyesi Muhammed ETYEMEZ
Kastamonu Üniversitesi, Türkiye |
|
Cafer Tayer Isler
|
| Özet |
| Endotoxemic shock is a severe complication characterized by multiple organ failure, hypotension, and impaired tissue perfusion, all contributing to high morbidity and mortality. Recent studies have highlighted the anti-inflammatory and antioxidant properties of tomentosin. This study investigates the protective effects of tomentosin against lipopolysaccharide (LPS)-induced cardiac injury and elucidates its underlying mechanisms. Mice were pre-treated with tomentosin before the LPS administration. Subsequently, cardiac injury markers, oxidative stress parameters, inflammatory mediators, and Nrf-2/NF-κB protein expression levels were analysed. The results demonstrated that tomentosin significantly reduced Troponin and CK-MB levels, alleviated oxidative stress, and suppressed inflammatory responses. Furthermore, tomentosin inhibited NF-κB activation while enhancing Nrf-2 expression. In conclusion, our findings suggest that tomentosin exerts cardioprotective effects by modulating the Nrf-2/NF-κB pathway, positioning it as a potential therapeutic candidate for preventing LPS-induced cardiac dysfunction. |
| Anahtar Kelimeler |
| Lipopolysaccharide | Tomentosin | Inflammation | Cardiac injury | Sepsis | Nrf-2/NF-kappa B |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | European Journal of Pharmacology |
| Dergi ISSN | 0014-2999 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 06-2025 |
| Cilt No | 996 |
| Doi Numarası | 10.1016/j.ejphar.2025.177589 |
| Makale Linki | https://doi.org/10.1016/j.ejphar.2025.177589 |
| Atıf Sayıları | |
| WoS | 1 |
