Tomentosin mitigates the LPS induced cardiac injury by regulating Nrf-2/Nf-κβ pathway in mice
Yazarlar (5)
Prof. Dr. Mehmet Güvenç Hatay Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. Tuba Aydın Ağrı İbrahim Çeçen Üniversitesi, Türkiye
Doç. Dr. Tuncer Kutlu Hatay Mustafa Kemal Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed ETYEMEZ Kastamonu Üniversitesi, Türkiye
Prof. Dr. Cafer Tayer İşler Hatay Mustafa Kemal Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | European Journal of Pharmacology (Q1) | ||
| Dergi ISSN | 0014-2999 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2025 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 01-06-2025 |
| Cilt / Sayı / Sayfa | 996 / 1 / 177589– | DOI | 10.1016/j.ejphar.2025.177589 |
| Makale Linki | https://doi.org/10.1016/j.ejphar.2025.177589 | ||
| UAK Araştırma Alanları |
Veteriner Fizyolojisi
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| Özet |
| Endotoxemic shock is a severe complication characterized by multiple organ failure, hypotension, and impaired tissue perfusion, all contributing to high morbidity and mortality. Recent studies have highlighted the anti-inflammatory and antioxidant properties of tomentosin. This study investigates the protective effects of tomentosin against lipopolysaccharide (LPS)-induced cardiac injury and elucidates its underlying mechanisms.Mice were pre-treated with tomentosin before the LPS administration. Subsequently, cardiac injury markers, oxidative stress parameters, inflammatory mediators, and Nrf-2/NF-κB protein expression levels were analysed.The results demonstrated that tomentosin significantly reduced Troponin and CK-MB levels, alleviated oxidative stress, and suppressed inflammatory responses. Furthermore, tomentosin inhibited NF-κB activation while enhancing Nrf-2 expression.In conclusion, our findings … |
| Anahtar Kelimeler |
| Cardiac injury | Inflammation | Lipopolysaccharide | Nrf-2/NF-κB | Sepsis | Tomentosin |
Science Direct
Tomentosin mitigates the LPS induced cardiac injury by regulating Nrf-2/Nf-κβ pathway in mice
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 5 |
| Scopus | 5 |
| Google Scholar | 5 |