Exploring the Molecular Basis of Anticancer Activity in Various Mushroom Species Against Colorectal Cancer Cells
Yazarlar (5)
İpek Ceylan
Kastamonu Üniversitesi, Türkiye
Kastamonu Üniversitesi, Türkiye
Doç. Dr. Dilşad ÖZERKAN Kastamonu Üniversitesi, Türkiye
Doç. Dr. Nuray EMİN Kastamonu Üniversitesi, Türkiye
Prof. Dr. Ilgaz Akata Ankara Üniversitesi, Türkiye
Prof. Dr. Ergin Murat ALTUNER Kastamonu Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Letters in Drug Design and Discovery (Q4) | ||
| Dergi ISSN | 1570-1808 Dergi Bilgileri (2024) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 12-2024 |
| Cilt / Sayı / Sayfa | 21 / 18 / 4378–4388 | DOI | 10.2174/0115701808324049241108063414 |
| Makale Linki | https://www.benthamdirect.com/content/journals/lddd/10.2174/0115701808324049241108063414 | ||
| UAK Araştırma Alanları |
Biyokimya
Mikrobiyoloji
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| Özet |
| Background Mushrooms are shown to protect against the side effects of cancer. Therefore, mushrooms with proven anticancer properties and active ingredients are fascinating in the search for new cancer drugs.Objective In this study, the effects of extracts from Hericium coralloides (M1), Lactarius deliciosus (M2), Lepista nuda (M3), Pleurotus ostreatus (M4), and Suillus collinitus (M5) together on HCT116 were investigated. Mesenchymal stem cells (MSCs) were used to study the effect on healthy cells.Methods MTT was used to determine cell viability. Dose-response curves were generated, the IC50 values of the compounds were calculated, and the effect of the extracts was compared using it. The FTIR was used to analyze the quantitative changes of the cellular components.Results and Discussion The evaluation of the IC50 values of all fungal species showed that they … |
| Anahtar Kelimeler |
| Antiproliferation | colorectal cancer | cytotoxicity | FTIR spectroscopy | mushroom | pharmaceutical research and development (R&D) |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 3 |