Improved apoptosis and mitochondrial dysfunction: the potential of carmofur-platinum nanoparticles
Yazarlar (6)
Gökçe Erdemir Cilasun Biruni Üniversitesi, Türkiye
Doç. Dr. Dilşad ÖZERKAN Kastamonu Üniversitesi, Türkiye
Prof. Dr. İshak Afşin Kariper Erciyes Üniversitesi, Türkiye
Esra Sert İstanbul Tıp Fakültesi, Türkiye
Işık Neslişah Korkut
İstanbul Tıp Fakültesi, Türkiye
İstanbul Tıp Fakültesi, Türkiye
Doç. Dr. Ferdane Danışman Kalındemirtaş Bilecik Şeyh Edebali Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Biomedical Materials Bristol (Q2) | ||
| Dergi ISSN | 1748-6041 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 04-2025 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 23-04-2025 |
| Cilt / Sayı / Sayfa | 20 / 3 / 35024–0 | DOI | 10.1088/1748-605X/adcbfa |
| Makale Linki | https://doi.org/10.1088/1748-605x/adcbfa | ||
| UAK Araştırma Alanları |
Hücre Biyolojisi
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| Özet |
| Despite their impact on cancer therapy, limitations such as systemic toxicity and drug resistance are encountered with platinum-based drugs. This study explores the potential of combining PtIV-based NP with carmofur (Car) to address these issues. In this study, platinum nanoparticles (PtNPs) and Car-loaded PtNP (Car@PtNP) were synthesized and their cytotoxic and apoptotic effects on colorectal and breast cancer cells were evaluated. Following characterization of the synthesized NPs by dynamic light scattering, UV–VIS spectroscopy, FTIR, and STEM, it was found that the average size of PtNPs was 55.42 nm and the size increased to approximately 186.06 nm upon synthesis of Car@PtNP. MTT assays demonstrated that Car@PtNP exhibited higher levels of cellular toxicity than carmofur alone. While it significantly decreased cell viability in both colon and breast cancer cells, its toxicity to HUVEC cells was … |
| Anahtar Kelimeler |
| cancer treatment | carmofur | cytotoxicity | platinum nanoparticles | research and development (R&D) |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |