| Yazarlar (6) |
Gökçe Erdemir Cilasun
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Dilşad Özerkan
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Ishak Afsin Kariper
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Esra Sert
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Işık Neslişah Korkut
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Ferdane Danışman Kalındemirtaş
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| Özet |
| Despite their impact on cancer therapy, limitations such as systemic toxicity and drug resistance are encountered with platinum-based drugs. This study explores the potential of combining PtIV-based NP with Carmofur (Car) to address these issues. In this study, platinum nanoparticles (PtNP) and Car-loaded PtNP (Car@PtNP) were synthesized and their cytotoxic and apoptotic effects on colorectal and breast cancer cells were evaluated. Following characterization of the synthesized NPs by DLS, UV-VIS spectroscopy, FTIR, and STEM, it was found that the average size of PtNPs was 55.42 nm and the size increased to approximately 186.06 nm upon synthesis of Car@PtNP. MTT assays demonstrated that Car@PtNP exhibited higher levels of cellular toxicity than carmofur alone. While it significantly decreased cell viability in both colon and breast cancer cells, its toxicity to HUVEC cells was minimal. Treatment of ... |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Biomedical Materials |
| Dergi ISSN | 1748-605X Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 04-2025 |
| Doi Numarası | 10.1088/1748-605X/adcbfa |
| Makale Linki | https://doi.org/10.1088/1748-605X/adcbfa |
| Atıf Sayıları |
