| Yazarlar (5) |
Dr. Öğr. Üyesi Mehmet Akif BİLDİRİCİ
Kastamonu Üniversitesi, Türkiye |
Yüksel Aliyazicioǧlu
Karadeniz Teknik Üniversitesi Tip Fakültesi, Türkiye |
|
Hüseyin Yaman
Karadeniz Teknik Üniversitesi Tip Fakültesi, Türkiye |
|
Süleyman Caner Karahan
Karadeniz Teknik Üniversitesi Tip Fakültesi, Türkiye |
|
Asim Örem
Karadeniz Teknik Üniversitesi Tip Fakültesi, Türkiye |
| Özet |
| Objectives: Reference change value (RCV) is an objective tool that indicates whether the change between consecutive measurements is clinically significant. This study aimed to determine the instrument-specific RCVs of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), thyroglobulin (Tg), thyroglobulin antibody (Anti-Tg), and thyroperoxidase antibody (Anti-TPO) tests, which are routinely analyzed for the diagnosis, case-finding, and screening of thyroid diseases. This cross-sectional study was conducted between January 1 and December 31, 2018. The twelve-month mean analytical imprecision (CVA) was calculated from internal quality control data for each test on three different instruments. All tests' individuality index (II) was calculated using the biological variation data. RCVs were determined by both conventional and logarithmic approaches. It was shown that the II of all tests was 0.6 and below. Upward logarithmic RCVs were slightly higher than conventional RCVs, while downward logarithmic RCVs were lower (e.g., conventional RCV for TSH 39%, whereas upward and downward RCVs 48 and 32%, respectively). Due to high individuality, the results of thyroid-related biomarkers would be more appropriate to evaluate with RCV instead of reference interval. Instrument-specific RCVs should be determined because the analytical imprecision of analyzers may vary. Most presentations to the hospital are not healthy individuals, so logarithmic RCV could provide a more accurate assessment of significant change. |
| Anahtar Kelimeler |
| biological variation | biomarkers | reference change value | thyroid |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Turkish Journal of Biochemistry |
| Dergi ISSN | 0250-4685 |
| Dergi Grubu | Q4 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2025 |
| Sayı | 1 |
| Doi Numarası | 10.1515/tjb-2024-0200 |
| Atıf Sayıları |
