BNB-BnNn Nano-Motor in Binding with ACC (tRNA) Nucleotides as an Amino Acid Detector in Ribosome: QM/MM & Monte Carlo Studies
Yazarlar (2)
Prof. Dr. Majıd MONAJJEMI Islamic Azad University, Central Tehran Branch, İran
Dr. Öğr. Üyesi Fatemeh MOLLAAMIN Kastamonu Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SCOPUS dergilerinde yayınlanan tam makale)
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| Dergi Adı | Biointerface Research in Applied Chemistry | ||
| Dergi ISSN | 2069-5837 Wos Dergi Scopus Dergi | ||
| Makale Dili | İngilizce | Basım Tarihi | 06-2023 |
| Cilt / Sayı / Sayfa | 13 / 3 / 254–0 | DOI | 10.33263/BRIAC133.254 |
| Makale Linki | https://biointerfaceresearch.com/wp-content/uploads/2022/06/BRIAC133.254.pdf | ||
| UAK Araştırma Alanları |
Fen Bilimleri ve Matematik
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| Özet |
| The electromagnetic non-bonded interactions of BNB molecule inside the BnNn (such as B12N12, B15N15, and B18N18) ring as a detector for tRNA-Amino acid conjugation has been investigated by QM/MM & Monte Carlo methods. In this study, we have shown that the BNB-BnNn systems can work as a nano rotor-stator for detecting tRNA during the tRNA-Amino-acid conjugation. We have employed the B12N12-tRNA (glu), B12N12–tRNA (phe) and B12N12-BNB-tRNA (arg) systems coupled with BN (-, 0,+) B inside the B12N12 ring (as a rotor)(n= 12, 15, 18). We have shown that the tRNA as an extrinsic factor (stator) is set in the BNB-B12N12 system due to the generation of radical, anion, and cation forms of BN (-, 0,+) B. We have also calculated the tRNA-BNB-B12N12 and obtained quantized transitional frequencies among the forms of radical, anionic, and cationic. The three frequencies have been yielded as νr-c) 486948.498 GHz, νa-c) 1792900.812 GHz, and νr-a) 2507076.816 GHz. It can be seen that all observed frequencies appeared in the IR and macro wave regions. |
| Anahtar Kelimeler |
| BnNn ring | Monte Carlo | ribosome | tRNA |
| Atıf Sayıları | |
| Scopus | 1 |
| Google Scholar | 1 |