Postmortem Temporal Changes in Liver and Spleen Stiffness: Evaluation with Shear Wave Elastography in a Rat Model
Yazarlar (7)
Doç. Dr. İsmail TAŞKENT Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Selçuk Başer Kastamonu Training And Research Hospital, Türkiye
Doç. Dr. Bünyamin ECE Kastamonu Üniversitesi, Türkiye
Serbülent Kılıç
Kastamonu Üniversitesi, Türkiye
Kastamonu Üniversitesi, Türkiye
Doç. Dr. Uğur AKPULAT Kastamonu Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Nurtaç SARIKAŞ Kastamonu Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Diagnostics (Q1) | ||
| Dergi ISSN | 2075-4418 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2025 |
| Cilt / Sayı / Sayfa | 15 / 8 / 14–0 | DOI | 10.3390/diagnostics15080958 |
| Makale Linki | https://www.mdpi.com/2075-4418/15/8/958 | ||
| Özet |
| Background/Objectives: Postmortem changes in tissue stiffness and organ morphology are critical for forensic medicine and pathology. Shear wave elastography (SWE) has emerged as a non-invasive tool to assess tissue stiffness, yet its potential for postmortem interval estimation remains underexplored. While previous studies have demonstrated early postmortem alterations in tissue elasticity, the temporal progression of these changes in different organs is not fully understood. This study aims to investigate the temporal changes in liver and spleen stiffness during the postmortem period using SWE and to evaluate the predictive potential of elastographic parameters for postmortem interval estimation. Methods: Twelve male Sprague–Dawley rats were sacrificed via cervical dislocation following deep anesthesia. Postmortem liver and spleen measurements, including longitudinal and short diameters and SWE values (kPa), were recorded at 0, 2, 4, 6, 9, 12, 18, 24, and 36 h. All elastographic measurements were obtained using a 5 mm circular region of interest (ROI) for the liver and a 3 mm ROI for the spleen. Changes over time were analyzed using repeated measures ANOVA, with post hoc Bonferroni corrections applied where necessary. Additionally, Receiver Operating Characteristic (ROC) curve analysis and binary logistic regression analysis were performed to assess the predictive accuracy of SWE parameters in estimating postmortem time. Results: Postmortem liver and spleen stiffness exhibited a significant declining trend over time (p < 0.001, η2 = 0.749 and η2 = 0.810, respectively). Liver and spleen dimensions initially increased … |
| Anahtar Kelimeler |
| liver stiffness | postmortem | rat model | shear wave elastography | spleen stiffness |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |