Investigation of Chronic Changes in Hydronephrotic and Contralateral Kidneys in Rats with Unilateral Ureteral Obstruction
Yazarlar (8)
Doç. Dr. Tuncer Kutlu Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Ufuk Kaya Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Ziya Yurtal Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. Mehmet Guvenc Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Huseyin Ozkan Mustafa Kemal Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed ETYEMEZ Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ibrahim Alakus Mustafa Kemal Üniversitesi, Türkiye
Arş. Gör. Hasan Huseyin Keceli Mustafa Kemal Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Molecular Biology Reports (Q3) | ||
| Dergi ISSN | 0301-4851 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 04-2025 |
| Kabul Tarihi | 31-03-2025 | Yayınlanma Tarihi | 22-04-2025 |
| Cilt / Sayı / Sayfa | 52 / 1 / 413–0 | DOI | 10.1007/s11033-025-10486-3 |
| Makale Linki | https://doi.org/10.1007/s11033-025-10486-3 | ||
| UAK Araştırma Alanları |
Veteriner Fizyolojisi
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| Özet |
| BackgroundAnimal models of chronic kidney disease are important experimental tools used to validate new mechanisms and potential innovations, as well as to investigate therapeutic interventions before clinical trials in humans. This study aimed to determine the chronic changes occurring in the obstructed kidneys (OK) and the contralateral (CL) kidneys in unilateral ureteral obstruction (UUO) in rats.Methods and resultsIn the study, three groups (n:6) were formed. It was observed that dilated tubules decreased at 28 days compared to 14 days, while mononuclear cell infiltration and fibrosis increased. In the CL kidneys, glutathione (GSH) was lower compared to the control group (CG) at 14 days; at 28 days, malondialdehyde (MDA) was elevated, and GSH and catalase (CAT) levels were reduced. Nuclear factor erythroid 2--related factor 2 (NRF-2) protein expression was lower in the OK compared to the CL kidneys ... |
| Anahtar Kelimeler |
| BAX | BCL-2 | COX-2 | NRF-2 | Oxidative stress | UUO |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 1 |