Effect of Salbutamol on the Disposition Kinetics of Levofloxacin in the Plasma and Lung of Rats
Yazarlar (3)
Prof. Dr. Halis Uğuz Türkiye
Prof. Dr. Orhan Çorum Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | CURRENT DRUG METABOLISM (Q3) | ||
| Dergi ISSN | 1389-2002 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2024 |
| Cilt / Sayı / Sayfa | 25 / 6 / 425–430 | DOI | 10.2174/0113892002314136240816094609 |
| Makale Linki | https://www.benthamdirect.com/content/journals/cdm/10.2174/0113892002314136240816094609 | ||
| UAK Araştırma Alanları |
Tıbbi Farmakoloji
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| Özet |
| BackgroundAntibiotics and bronchodilator drugs can be used together in respiratory distress caused by bacterial infections. Levofloxacin (LVX) and Salbutamol (SLB) can be used simultaneously in respiratory distress. However, there have been no investigations on how the concurrent use of SLB can affect the pharmacokinetics of LVX in rats.ObjectiveThe purpose of this study was to investigate the influence of SLB on the plasma and lung pharmacokinetics of LVX in rats.MethodsA total of 132 rats were randomly assigned to two groups: LVX (n=66) and LVX+SLB (n=66). LVX (intraperitoneal) and SLB (oral) were administered to rats at doses of 50 and 3 mg/kg, respectively. The concentrations of LVX in the plasma and lungs were determined through the utilization of high-performance liquid chromatography along with UV. Pharmacokinetic parameters were assessed by non-compartmental analysis.ResultsThe … |
| Anahtar Kelimeler |
| HPLC | levofloxacin | optical L-isomer | pharmacokinetics | salbutamol | liquid chromatography |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Google Scholar | 1 |