Therapeutic potential of young plasma in reversing age-related liver inflammation via modulation of NLRP3 inflammasome and necroptosis
Yazarlar (7)
Burcu Baba Yüksek İhtisas Üniversitesi, Türkiye
Taha Ceylani Muş Alparslan Üniversitesi, Türkiye
Hikmet Taner Teker Ankara Medipol University, Türkiye
Seda Keskin Van Yüzüncü Yıl Üniversitesi, Türkiye
Arş. Gör. Dr. Aysun İNAN GENÇ Kastamonu Üniversitesi, Türkiye
Rafig Gurbanov Bilecik Şeyh Edebali Üniversitesi, Türkiye
Eda Açıkgöz Van Yüzüncü Yıl Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Biogerontology (Q2) | ||
| Dergi ISSN | 1389-5729 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 05-2025 |
| Cilt / Sayı / Sayfa | 26 / 3 / 117–0 | DOI | 10.1007/s10522-025-10260-9 |
| Makale Linki | https://doi.org/10.1007/s10522-025-10260-9 | ||
| Özet |
| The phenomenon of inflammaging, characterized by an increase in low-grade chronic inflammation, is closely associated with diseases related to liver dysfunction. This study investigated daily plasma exchange between 5-week-old and 24-month-old Sprague Dawley rats for 30 days, focusing on protein secondary structures, NLRP3 inflammasome, and necroptosis. Conformation changes in protein secondary structures were identified by infrared spectroscopy-based pattern recognition analysis. Liver biopsies with histochemical and immunohistochemical staining were used to assess molecules associated with inflammation, necroptosis and NLRP3 inflammasome complex. Expression levels of NLRP3 components were determined by qPCR. Enhanced random coils, 310 helices, β-turns, and loop structures were identified in old rats and young rats with old plasma. Young rats and old rats with young plasma … |
| Anahtar Kelimeler |
| Inflammaging | Infrared spectroscopy | Necroptosis | NLRP3 Inflammasome | Plasma exchange |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 4 |
| Scopus | 4 |
| Google Scholar | 4 |