Propolis Extract Reduces Doxorubucin-Induced Brain Damage by Regulating Inflammation, ER Stress, Oxidative Stress, and Apoptosis
Yazarlar (5)
Volkan Gelen Kafkas Üniversitesi, Veteriner Fakültesi, Türkiye
Mehmet Başeğmez Pamukkale Üniversitesi, Türkiye
İnan Dursun Bingöl Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Prof. Dr. Adem Kara Erzurum Technical University, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Food Science and Nutrition (Q2) | ||
| Dergi ISSN | 2048-7177 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2025 |
| Cilt / Sayı / Sayfa | 13 / 4 / 17–0 | DOI | 10.1002/fsn3.70194 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/fsn3.70194 | ||
| Özet |
| Doxorubicin (DOX) is the most widely used chemotherapeutic agent to treat various tumors. DOX treatment can damage many organs, including the brain, by causing oxidative stress. Several antioxidant substances can lessen the effects of DOX or make antioxidant defense systems work faster. Propolis (PROP) is a powerful agent with various healing effects, including antioxidant, antiproliferative, and anti‐inflammatory. The point of this study is to look at the histopathological changes, apoptosis, and antioxidant effects of DOX on brain damage in rats. To find out what kinds of phytochemicals were in PROP from the Karlıova region of Bingöl province, ultra‐high‐performance liquid chromatography (UHPLC‐Orbitrap‐HRMS) was used. Then, we made an ethanol extract of it. A total of 28 healthy male Wistar albino rats, each 12 weeks old and weighing between 220 and 250 g, were included in the study. Rats were … |
| Anahtar Kelimeler |
| apoptosis | DOX | inflammation | oxidative stress | propolis extract | UHPLC-Orbitrap-HRMS |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 7 |
| Scopus | 6 |
| Google Scholar | 8 |