Investigation of the protective effect of beta caryophyllene against indomethacin-induced gastric ulcer in rats: in vivo and in vitro study
Yazarlar (6)
Dr. Öğr. Üyesi Merve Bolat Atatürk Üniversitesi, Türkiye
Fikret Çelebi Atatürk Üniversitesi, Türkiye
Prof. Dr. Emin Şengül Atatürk Üniversitesi, Türkiye
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Prof. Dr. Serkan Yıldırım Kyrgyz-Turkish Manas University, Kırgızistan
Doç. Dr. İsmail Bolat Atatürk Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Naunyn Schmiedeberg S Archives of Pharmacology (Q2) | ||
| Dergi ISSN | 0028-1298 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2025 |
| Cilt / Sayı / Sayfa | 398 / 11 / 15885–15903 | DOI | 10.1007/s00210-025-04269-7 |
| Makale Linki | https://link.springer.com/content/pdf/10.1007/s00210-025-04269-7.pdf | ||
| Özet |
| In this study, the protective and healing effects of beta-caryophyllene (BCP) on gastric mucosa in indomethacin (INDO)-induced gastric ulcer model were investigated. In the study, 116 male Sprague–Dawley rats were used. In in vivo experiments, rat was administered doses of 50–100–200 mg/kg BCP and 5 mg/kg omeprazole for 14 days, and indomethacin (100 mg/kg) was given on the last day. In in vitro experiments, the effects of BCP (250–500–1000 µg/ml) on gastric motility and acid secretion were examined by isolated organ bath method. It was found that INDO treatment increased MDA level in gastric tissue, but decreased GPx and SOD activities. Nrf2 and HO-1 levels were decreased in INDO-treated groups. INDO increased TNF-α, IL-1β, and NF-κB levels and iNOS activity, but decreased COX-1 activity and PGE2 levels. INDO induced ER stress and increased GRP78, ATF4, ATF6, p-IRE1, sXBP1, eIF2-α … |
| Anahtar Kelimeler |
| Apoptosis | Beta caryophyllene | ER stress | Gastric ulcer | Inflammation | Oxidative stress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 5 |
| Google Scholar | 8 |