Effects of Apilarnil on Type 2 Diabetes-Induced IRS-1/PI3K/Akt Mediated Insulin Resistance in Male Rats
Yazarlar (7)
Öğr. Gör. Fatma Karagözoğlu Dokuz Eylül Üniversitesi, Türkiye
Dr. Öğr. Üyesi Emre Şahin Bingöl Üniversitesi, Türkiye
Dr. Öğr. Üyesi Şule Melek Bingöl Üniversitesi, Türkiye
Saliha Bediz Şahin
Ankara Üniversitesi, Türkiye
Dr. Öğr. Üyesi Recep Hakkı Koca Bingöl Üniversitesi, Türkiye
Prof. Dr. Hayati Yüksel Bingöl Üniversitesi, Türkiye
Dr. Öğr. Üyesi Alper GÜNGÖREN Kastamonu Üniversitesi, Türkiye
Makale Türü Açık Erişim Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı ACS Omega (Q2)
Dergi ISSN 2470-1343 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI-Expanded
Makale Dili İngilizce Basım Tarihi 06-2025
Cilt / Sayı / Sayfa 10 / 23 / 25027–25038 DOI 10.1021/acsomega.5c02662
Makale Linki https://doi.org/10.1021/acsomega.5c02662
Özet
Diabetes is one of the most important chronic and metabolic health problems seen as an epidemic of the 21st century. The incidence of diabetes is gradually increasing, and different methods are used to treat it. Apitherapy products such as honey, propolis, royal jelly, and bee venom can be used as an alternative to treat diabetes and reduce symptoms. One of these apitherapy products is Apilarnil, which has not yet become popular. The hypolipidemic, hepatoprotective, androgenic, anabolic, and immune system enhancing properties of Apilarnil indicate that it may be effective in the treatment of type 2 diabetes or in reducing the symptoms. The study aimed to determine the therapeutic effect of Apilarnil on insulin resistance and the possible underlying mechanism. In the study, 40 8 week-old male Wistar albino rats were used. The rats were divided into 5 groups as Control, Diabetes, Diabetes + Api1 (125 mg/kg/day …
Anahtar Kelimeler
BM Sürdürülebilir Kalkınma Amaçları
Atıf Sayıları
Web of Science 2
Scopus 2
Google Scholar 2
Effects of Apilarnil on Type 2 Diabetes-Induced IRS-1/PI3K/Akt Mediated Insulin Resistance in Male Rats

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