| Yazarlar (5) |
Gamze Altun
Ondokuz Mayıs Üniversitesi, Türkiye |
|
Juman Almasaad
|
|
Muzaffer Başak Tunalı
İstanbul Üniversitesi-Cerrahpaşa, Türkiye |
Doç. Dr. Kıymet Kübra TÜFEKCİ
Kastamonu Üniversitesi, Türkiye |
|
Süleyman Kaplan
Ondokuz Mayıs Üniversitesi, Türkiye |
| Özet |
| A common complication of diabetes mellitus (DM), peripheral neuropathy, is frequently discussed. This research examined the role of curcumin-induced treatment models against the devastating effects of diabetes. Wistar albino female rats (n= 56) were randomly divided into seven groups. The control group did not receive any special procedure. Five mL/kg of corn oil by intragastric gavage was given to the Sham group. Streptozotocin was administered intraperitoneally at 50 mg/kg in the DM group. Curcumin (30 mg/kg) was given to the treatment groups for 14 days. These were then divided into three further groups: the early treatment group (DC1) was applied curcumin seven days after DM induction, the late treatment group (DC2) after 21 days, and the simultaneous treatment group (DC3) received curcumin concurrently with induction. The curcumin group received only 30 mg/kg of curcumin for 14 days. 30 mg/kg of curcumin was given to the DM+ curcumin group (DC1) via intragastric gavage once daily for 14 days, starting seven days after diabetes induction. The DM+ curcumin group (DC2) received 30 mg/kg curcumin intragastric gavage once daily for 14 days, starting 21 days after the onset of diabetes. 30 mg/kg of curcumin was applied to the DM+ curcumin (Cur) group (DC3) via intragastric gavage once daily for 14 days, simultaneously with the onset of diabetes. 30 mg/kg of curcumin was given to the Cur group via intragastric gavage once daily for 14 days. Stereological methods were used for morphoquantitative analysis of myelin thickness, myelinated axon areas, and axon numbers. The axon area decreased in the DM group compared … |
| Anahtar Kelimeler |
| Curcumin | Diabetes Mellitus | Neuroprotection | Sciatic nerve | Stereology |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | The Pakistan Veterinary Journal |
| Dergi ISSN | 0253-8318 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | Türkçe |
| Basım Tarihi | 01-2025 |
| Cilt No | 45 |
| Sayı | 1 |
| Sayfalar | 344 / 351 |
| Doi Numarası | 10.29261/pakvetj/2025.004 |
| Makale Linki | https://doi.org/10.29261/pakvetj/2025.004 |
| Atıf Sayıları | |
| Google Scholar | 1 |
