Safranal Alleviates Cyclophosphamide Induced Testicular Toxicity in Rats
Yazarlar (5)
Mustafa Cellat Hatay Mustafa Kemal Üniversitesi, Türkiye
Prof. Dr. İlker Yavaş Hatay Mustafa Kemal Üniversitesi, Türkiye
Doç. Dr. Ahmet Uyar Hatay Mustafa Kemal Üniversitesi, Türkiye
Dr. Öğr. Üyesi Muhammed ETYEMEZ Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mehmet Güvenç Hatay Mustafa Kemal Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Food Science and Nutrition (Q2) | ||
| Dergi ISSN | 2048-7177 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 06-2025 |
| Kabul Tarihi | 05-06-2025 | Yayınlanma Tarihi | 01-06-2025 |
| Cilt / Sayı / Sayfa | 13 / 6 / – | DOI | 10.1002/fsn3.70452 |
| Makale Linki | https://doi.org/10.1002/fsn3.70452 | ||
| UAK Araştırma Alanları |
Veteriner Fizyolojisi
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| Özet |
| Safranal, the principal component of Crocus sativus essential oil, is primarily responsible for the characteristic aroma and distinct odor of saffron. Cyclophosphamide (CP), a chemotherapeutic agent commonly used in the treatment of both malignant and non‐malignant conditions, is known to induce cytotoxicity in various tissues, particularly within the male reproductive system. This study aimed to investigate the protective effects of safranal against CP‐induced reproductive toxicity in Wistar albino rats. CP was administered orally at a dose of 15 mg/kg once per week for 56 days to establish a model of testicular toxicity. In parallel, the treatment group received safranal via oral gavage at a daily dose of 200 mg/kg for the same duration. At the end of the treatment period, spermatological, biochemical, and histological analyses were performed on collected tissue samples. CP administration led to increased dead/live … |
| Anahtar Kelimeler |
| cyclophosphamide | male infertility | safranal | testicular toxicity |
| Atıf Sayıları | |
| Scopus | 11 |
| Google Scholar | 9 |