Maternal high-fat diet impairs cognitive performance by altering hippocampal GRP78/PERK axis and BDNF expression in adult female rat offspring: the potential protective role of N acetylcysteine
Yazarlar (5)
Dr. Öğr. Üyesi Elfide Gizem Bakirhan Adıyaman Üniversitesi, Türkiye
Doç. Dr. Kıymet Kübra TÜFEKCİ Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Furkan Bakırhan Türkiye
Dr. Öğr. Üyesi Solmaz Susam Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF MOLECULAR HISTOLOGY (Q3) | ||
| Dergi ISSN | 1567-2379 Dergi Bilgileri (2025) | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 06-2025 |
| Cilt / Sayı / Sayfa | 56 / 3 / 189–0 | DOI | 10.1007/s10735-025-10471-x |
| Makale Linki | https://doi.org/10.1007/s10735-025-10471-x | ||
| UAK Araştırma Alanları |
Histoloji ve Embriyoloji
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| Özet |
| Maternal high fat diet (HFD) affects the neurodevelopment of offspring and has long-term consequences on cognitive behavior. This study investigated changes occurring in GRP78 and PERK, important markers of endoplasmic reticulum stress (ERS) signaling, in the hippocampus of female adult rats exposed to maternal HFD, and in brain-derived neurotrophic factor (BDNF) signaling, with its important role in the regulation of cognitive behavior, and the potential neuroprotective effects of N-acetylcysteine (NAC) against these changes. A maternal obesity model was created with HFD (60% kcal). NAC (150 mg/kg) was administered intragastrically to both the NAC and HFD + NAC groups. The animals were mated at 12 weeks of age. The same diet was maintained throughout pregnancy and lactation. All female rat pups were subjected to the water maze test at eight weeks of age. Hippocampal GRP78 and PERK … |
| Anahtar Kelimeler |
| BDNF | Cognitive performance | GRP78 | PERK | Maternal high fat diet |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Google Scholar | 3 |