| Yazarlar (2) |
Elfide Gizem Bakırhan
Adıyaman Üniversitesi, Türkiye |
Doç. Dr. Kıymet Kübra TÜFEKCİ
Kastamonu Üniversitesi, Türkiye |
| Özet |
| The aim of this study was to determine whether N-acetylcysteine (NAC) administration attenuates the adverse effects on the hypothalamic gastric axis in the offspring of rat dams given a high-fat diet (HFD) during pregnancy and lactation. A maternal obesity model was established using a 60% k/cal HFD. Both the NAC and obesity+ NAC (Ob+ NAC) groups received NAC (150 mg/kg) by oral gavage from the beginning of pregnancy until postnatal day 25. All female pups were sacrificed at eight weeks of age. Arcuate (ARC) nucleus volumes were analyzed stereologically, and neuropeptide (NPY) concentrations were determined biochemically in hypothalamus tissues. Immunohistochemically, ghrelin expression was analyzed from stomach tissue sections, and ghrelin levels were determined in blood samples. The total volume of the ARC region and NPY concentrations increased in the obesity group. A tendency … |
| Anahtar Kelimeler |
| arcuate nucleus | ghrelin | maternal obesity | N-acetylcysteine |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Biology Bulletin |
| Dergi ISSN | 1062-3590 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | Türkçe |
| Basım Tarihi | 04-2025 |
| Cilt No | 52 |
| Sayı | 2 |
| Doi Numarası | 10.1134/S1062359024611327 |
| Makale Linki | https://doi.org/10.1134/s1062359024611327 |
| Atıf Sayıları |
