| Yazarlar (8) |
Mehmet Özbek
Burdur Mehmet Akif Ersoy Üniversitesi, Turkey |
|
Feyzullah Beyaz
Erciyes Üniversitesi, Turkey |
Doç. Dr. Mustafa HİTİT
Kastamonu Üniversitesi, Türkiye |
|
Mustafa Öztop
Faculty of Arts and Sciences, Turkey |
|
Harun Karaca
Burdur Mehmet Akif Ersoy Üniversitesi, Turkey |
|
Emel Ergün
Ankara Üniversitesi, Turkey |
|
Ahmet Cabir
Erciyes Üniversitesi, Turkey |
|
Levent Ergün
Ankara Üniversitesi, Turkey |
| Özet |
| VEGF signaling has a crucial role in regulating the differentiation and proliferation of spermatogonial stem cells, as well as controlling vascular permeability in the epididymis. VEGF primarily exerts its effects by binding to VEGFR-1, VEGFR-2, and VEGFR-3. The objective of this work was to assess the expression of these proteins in the rat testis and epididymis during postnatal development using immunohistochemical and Western blotting techniques. The presence of VEGF was exclusively observed in specialized germ cells subsequent to the elongated spermatid stage in the mature phase. VEGF expression was observed in Leydig cells at all phases of postnatal development, but only in mature Sertoli cells throughout the postpubertal and mature periods. Leydig cells demonstrated positive immunostaining for both VEGFR-1 and VEGFR-2, while Sertoli cells showed no positivity for either receptor. VEGFR-1 and VEGFR-2 expression was not observed in germ cells throughout the neonatal and prepubertal phases. VEGFR-1 expression was only present in germ cells at the elongated spermatid stage within the seminiferous tubules during the postpubertal and mature periods. Conversely, VEGFR-2 was detected in both elongated spermatids and spermatogonia. Different levels of VEGF, VEGFR-1, and VEGFR-2 expression were found in different parts of the epididymis. This study reports a differential expression pattern of VEGF, VEGFR-1, and VEGFR-2 in the testis and epididymis during postnatal development. Puberty appears to have an essential impact on overall expression profiles of these proteins. More studies are required to better understand the functions of VEGF and its receptors in male reproductive physiology. |
| Anahtar Kelimeler |
| Epididymis | Rat | Testis | VEGF | VEGFR-1 | VEGFR-2 |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Bratislava Medical Journal |
| Dergi ISSN | 0006-9248 Wos Dergi Scopus Dergi |
| Dergi Grubu | Q2 |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2025 |
| Sayı | 1 |
| Doi Numarası | 10.1007/s44411-025-00230-5 |
| Atıf Sayıları |
