Antagonism of 5-HT7 Receptors as a Promising Target for Gastric Cancer via Apoptotic Pathway
Yazarlar (7)
Doç. Dr. İrfan ÇINAR Kastamonu Üniversitesi, Türkiye
Doç. Dr. Busra Dincer Ondokuz Mayis Üniversitesi, Türkiye
Prof. Dr. Elif Cadirci Ataturk University, Faculty Of Medicine, Türkiye
Doç. Dr. Salih Kara Ataturk University, Faculty Of Medicine, Türkiye
Prof. Dr. Mehmet Ilhan Yildirgan Ataturk University, Faculty Of Medicine, Türkiye
Prof. Dr. Zekai Halici Ataturk University, Faculty Of Medicine, Türkiye
Saziye Sezin Palabiyik-Yucelik Ondokuz Mayis Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Journal of Biochemical and Molecular Toxicology (Q2) | ||
| Dergi ISSN | 1095-6670 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 01-2025 |
| Cilt / Sayı / Sayfa | 39 / 6 / 12–0 | DOI | 10.1002/jbt.70326 |
| Makale Linki | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jbt.70326 | ||
| Özet |
| Although current treatment strategies have improved clinical outcomes for gastric cancer, they present a challenging prognosis that necessitates novel therapeutic approaches. The 5‐HT7 receptor, a member of the serotonin receptor family, plays a significant role in influencing the pathogenesis of various cancer types. This study seeks to investigate the complex interactions among 5‐HT7 receptors, gastric cancer, and apoptotic processes. A comprehensive set of experimental techniques was employed, including in vitro staining assays for apoptosis assessment, real‐time PCR, and cell proliferation assays. The findings indicate that the 5‐HT7 receptor agonist enhances the proliferation of primary gastric tissue cancer cells and KATO‐III cells, whereas treatment with the 5‐HT7 receptor antagonist significantly inhibits cellular proliferation. Analysis of 5‐HT7 receptor mRNA expression in gastric cancer patient … |
| Anahtar Kelimeler |
| 5-HT7 receptors | caspase | KATO-III cells | LP44 | SB-269970 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Scopus | 2 |
| Google Scholar | 2 |