Consolidation of Ultrasound and Light: Silicon Phthalocyanine‐Based Sensitizer Therapeutic Agent for Synergetic Sonodynamic–Photodynamic Therapy of Breast Cancer

Cakmak, Hilal; Turkkol, Aysegul; Guzel, Emre; Kolac, Umut Kerem; Atmaca, Goknur Yasa; Kuznetsov, Aleksey E.; ÇAVUŞ, Muhammet Serdar; Yildiz, Mustafa Z.; Sobotta, Lukasz; Bilgin, Mehmet Dincer; Erdogmus, Ali

doi:10.1002/adtp.202500053

Consolidation of Ultrasound and Light: Silicon Phthalocyanine‐Based Sensitizer Therapeutic Agent for Synergetic Sonodynamic–Photodynamic Therapy of Breast Cancer

Yazarlar (11)
Hilal Cakmak Sakarya University Of Applied Sciences, Türkiye
Aysegul Turkkol Aydin Adnan Menderes University, Türkiye
Umut Kerem Kolac Aydin Adnan Menderes University, Türkiye
Goknur Yasa Atmaca Yıldız Teknik Üniversitesi, Türkiye
Aleksey E. Kuznetsov Universidad Técnica Federico Santa María, Şili
Prof. Dr. Muhammet Serdar ÇAVUŞ Kurum Bilgileri Mühendislik ve Mimarlık Fakültesi Biyomedikal Mühendisliği Biyomekanik Özgeçmiş Sayfası İletişim Bilgileri: (366)280-2913 KASTAMONU ÜNİVERSİTESİ BİYOMEDİKAL MÜHENDİSLİĞİ BÖLÜMÜ Kastamonu Üniversitesi, Türkiye
Mustafa Z. Yildiz Sakarya University Of Applied Sciences, Türkiye
Lukasz Sobotta Poznan University Of Medical Sciences, Polonya
Mehmet Dincer Bilgin Aydin Adnan Menderes University, Türkiye
Ali Erdogmus Yıldız Teknik Üniversitesi, Türkiye
Emre Guzel Sakarya University Of Applied Sciences, Türkiye

Devamını Göster

Özet

Sono-photodynamic therapy (SPDT), a useful technique applied in combination with photodynamic therapy (PDT) and sonodynamic therapy (SDT), reduces potential side effects compared to monotherapy. This study reports the photochemical and sono-photochemical properties and in vitro analysis of silicon (IV) phthalocyanine (SiPc), with a particular focus on its efficiency in singlet oxygen production. When photochemical investigations are conducted alone, the SiPc Φ∆ value is measured as 0.68; however, when light and ultrasound are combined, the value increased by 25% to 0.85 in sono-photochemical studies. The Q-band of the calculated SiPc UV–vis spectrum is found to be in very good agreement with the experimental data, with the computed oscillator strengths (the absorption intensities) for Q-band being higher than for B-band. Furthermore, the therapeutic effects of PDT and SPDT using SiPc are evaluated in MCF-7 and MDA-MB-231 breast cancer cell lines. The results demonstrated that SPDT, combining light and ultrasound, significantly enhanced cytotoxicity compared to PDT alone. Additionally, SPDT triggered pyroptosis, characterized by upregulation of NLRP3, CASP1, IL1B, and IL18, revealing a distinct mechanism of cell death. These findings suggest that SiPc-mediated SPDT amplifies oxidative stress and activates multiple cell death pathways, offering a promising and targeted approach for improving breast cancer therapy.

Anahtar Kelimeler

Makale Türü	Özgün Makale
Makale Alt Türü	SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale
Dergi Adı	Advanced Therapeutics
Dergi ISSN	2366-3987 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler	SCI-Expanded
Dergi Grubu	Q3
Makale Dili	İngilizce
Basım Tarihi	07-2025
Cilt No	8
Sayı	8
Doi Numarası	10.1002/adtp.202500053
Makale Linki	https://doi.org/10.1002/adtp.202500053

BM Sürdürülebilir Kalkınma Amaçları

Atıf Sayıları

Consolidation of Ultrasound and Light: Silicon Phthalocyanine‐Based Sensitizer Therapeutic Agent for Synergetic Sonodynamic–Photodynamic Therapy of Breast Cancer

Dergi Adı	Advanced Therapeutics
Yayıncı	Wiley-Blackwell Publishing Ltd
Açık Erişim	Hayır
ISSN	/ 2366-3987
CiteScore	6.6
SJR	0.865
SNIP	0.560

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Consolidation of Ultrasound and Light: Silicon Phthalocyanine‐Based Sensitizer Therapeutic Agent for Synergetic Sonodynamic–Photodynamic Therapy of Breast Cancer

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