| Yazarlar |
Doç. Dr. Mahmut GÜR
Kastamonu Üniversitesi, Türkiye |
Öğr. Gör. Merve ZURNACI
Kastamonu Üniversitesi, Türkiye |
Eda Altınöz
|
Prof. Dr. Nesrin ŞENER
Kastamonu Üniversitesi, Türkiye |
|
Çiğdem Şahin
Türkiye |
|
Merve Şahinturan
|
Prof. Dr. İzzet ŞENER
Kastamonu Üniversitesi, Türkiye |
Doç. Dr. Muhammet Serdar ÇAVUŞ
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. Ergin Murat ALTUNER
Kastamonu Üniversitesi, Türkiye |
| Özet |
| In this study, 1,3,4-thiadiazole derivatives were obtained from the reaction of benzophenone-4,4'-dicarboxylic acid and N-substitute-thiosemicarbazide compounds with each other. After the synthesis of the final products, some biological properties of these compounds such as antibiofilm, antimicrobial and efflux pump inhibiting efficiencies were evaluated. According to the MBC/MFC test, all the activities were found to be bacteriostatic, also, especially the biofilm inhibition activity of C1 against K. pneumoniae is noteworthy. In addition, C4 was observed to exhibit efflux pump inhibition activity in E. coli, whereas C2 and C3 in K. pneumoniae. The absorption and emission values of the molecules were obtained and electrochemical studies were performed. In addition; absorption, metabolism, distribution, excretion and toxicity (ADMET) scores were predicted using the pharmacokinetic properties of all 1,3,4-thiadiazole compounds. Finally, the electrochemical stabilities of the synthesized molecules have been analyzed by using cyclic voltammetry in 0.1 M TBAPF6 in DMSO as a supporting electrolyte. |
| Anahtar Kelimeler |
| Efflux pump inhibition,antibiofilm,antibacterial,ADMET,QSAR |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | Ulusal alan endekslerinde (TR Dizin, ULAKBİM) yayımlanan tam makale |
| Dergi Adı | Hittite Journal of Science and Engineering |
| Dergi ISSN | 2148-4171 |
| Dergi Tarandığı Indeksler | TR DİZİN |
| Makale Dili | Türkçe |
| Basım Tarihi | 06-2023 |
| Cilt No | 10 |
| Sayı | 2 |
| Sayfalar | 99 / 116 |
| Doi Numarası | 10.17350/HJSE19030000297 |
| Makale Linki | http://dx.doi.org/10.17350/hjse19030000297 |
| Atıf Sayıları | |
| Google Scholar | 1 |
