Chrysin Boosts the Cell Death and Anticancer Actions of Doxorubicin by Stimulating the TRPM2 Channel in Glioblastoma Cells
Yazarlar (2)
Doç. Dr. Yener YAZĞAN Kastamonu Üniversitesi, Türkiye
K. Yıldızhan Van Yüzüncü Yıl Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Molecular Biology (Q4) | ||
| Dergi ISSN | 0026-8933 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 07-2025 |
| Cilt / Sayı / Sayfa | 59 / 5 / 784–794 | DOI | 10.1134/S0026893325600710 |
| Makale Linki | https://doi.org/10.1134/s0026893325600710 | ||
| Özet |
| The prognosis for glioblastoma multiforme (GBM), the adult brain and spinal cord tumour with the poorest prognosis, has not improved enough with current therapies. Investigating potential molecular routes of tumour growth and metastasis and novel therapeutic methods are, therefore, obviously necessary. Although some natural substances have been shown to increase intracellular Ca2+ concentration and ROS generation by activating TRPM2 channel and potentiate the anticancer effects of doxorubicin (DOX), and chrysin (CHR) has been shown to enhance the anticancer effect of DOX, its anticancer effect through TRPM2-mediated Ca2+ homeostasis and ROS generation in glioblastoma tumour cells (DBTRG) has not been investigated. This work aimed to clarify the molecular processes behind the synergistic chemotherapeutic action of DOX and CHR in DBTRG cells. For this purpose, we investigated the … |
| Anahtar Kelimeler |
| chrysin | doxorubicin | glioblastoma | oxidative stress | TRPM2 |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |
| Google Scholar | 3 |