Cerebrospinal fluid estradiol fluctuations during the estrous cycle and their association with intraocular pressure and optic nerve sheath diameter in dogs: a first report
Yazarlar (9)
Dr. Öğr. Üyesi Candemir ÖZCAN Kastamonu Üniversitesi, Türkiye
Arş. Gör. Serkan BOZACI Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Berrak Işık DENİZ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Kenan Çağrı TÜMER Kastamonu Üniversitesi, Türkiye
Doç. Dr. Ömer DENİZ Kastamonu Üniversitesi, Türkiye
Doç. Dr. Tarık ŞAFAK Kastamonu Üniversitesi, Türkiye
Dr. Öğr. Üyesi Ayşe Başak DELLALBAŞI Kastamonu Üniversitesi, Türkiye
Prof. Dr. Özgür KAYNAR Kastamonu Üniversitesi, Türkiye
Prof. Dr. Elif DOĞAN Kastamonu Üniversitesi, Türkiye
| Makale Türü |
Özgün Makale
(SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
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| Dergi Adı | Veterinary Research Communications (Q2) | ||
| Dergi ISSN | 0165-7380 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 07-2025 |
| Cilt / Sayı / Sayfa | 49 / 5 / – | DOI | 10.1007/s11259-025-10820-x |
| Makale Linki | https://doi.org/10.1007/s11259-025-10820-x | ||
| UAK Araştırma Alanları |
Veteriner Biyokimyası
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| Özet |
| Objective: The relationship between optic nerve sheath diameter (ONSD), an indicator of intracranial pressure (ICP), and intraocular pressure (IOP) is controversial. The two aims of this study were; first, to investigate the effect of cerebrospinal fluid (CSF) estradiol (E2) and progesterone (P4) levels on ONSD and second, to investigate the relationship between ONSD and IOP in female dogs. Methods: IOP measurements were performed using rebound tonometer, and transpalpebral ultrasonographic assessment of the ONSD was conducted. CSF samples were collected, and E2 and P4 levels were quantified using enzyme-linked immunosorbent assay (ELISA). Multiple regression analysis was conducted to assess the relationships among the variables. Results: Multiple regression analyses on dogs found that the level of cerebrospinal fluid estradiol level (CSF-E2) significantly influenced left (L) ONSD (p = 0.0421, R² = 0.1551) and right (R) ONSD (p = 0.0216, R² = 0.1938). Systolic blood pressure (SBP) was a significant independent variable for left intraocular pressure (LIOP) (p = 0.0122, R² = 0.2261), while body weight was a significant predictor for right intraocular pressure (RIOP) (p = 0.0008, R² = 0.3679). Conclusions: This study revealed that CSF-E2 levels exert a significant influence on ONSD in dogs, whereas no direct association was observed between IOP and ONSD. These findings underscore the notion that ONSD is modulated not only by hemodynamic mechanisms but also by hormonal regulation. |
| Anahtar Kelimeler |
| Dog | Estradiol | Intraocular pressure | Optic nerve sheath diameter | Progesteron |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 1 |
| Scopus | 1 |