| Yazarlar |
Öğr. Gör. Dr. Merve ZURNACI
Kastamonu Üniversitesi, Türkiye |
Fatih Ünal
Türkiye |
|
Serkan Demir
Giresun Üniversitesi, Türkiye |
|
Prof. Dr. Mahmut GÜR
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. Nesrin ŞENER
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. İzzet ŞENER
Kastamonu Üniversitesi, Türkiye |
| Özet |
| The novel compounds bearing 1,3,4-thiadiazole moiety were obtained and their structures were identified using FT-IR, NMR methods, elemental, and mass analysis. UV-Vis and fluorescence spectra were obtained in six different polarity solvents. In addition, antimicrobial, antibiofilm, and the efflux pump inhibiting activities of the new compounds on K. pneumoniae, methicillin-resistant S. aureus (MRSA), E. coli, and C. albicans were investigated. Furthermore, druglikeness and ADMET properties of the compounds were determined. As a result, it was observed that some of the derivatives presented antimicrobial activity against K. pneumoniae, S. aureus, and C. albicans. But the MBC/MFC test showed that all the activities were bacteriostatic. In addition, these derivatives have the potential of using both inhibiting and activating biofilm formation depending on the concentration. 1,3,4-thiadiazole derivatives also presented good efflux pump inhibition in K. pneumoniae and E. coli. ADMET tests showed that 1,3,4-thiadiazole derivatives have the potential of being used as therapeutic compounds. |
| Anahtar Kelimeler |
| ADMET | antibacterial | antibiofilm | efflux pump inhibition | QSAR |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | CHEMISTRYSELECT |
| Dergi ISSN | 2365-6549 |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q3 |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2021 |
| Cilt No | 6 |
| Sayı | 45 |
| Sayfalar | 12571 / 12581 |
| Doi Numarası | 10.1002/slct.202103214 |
| Makale Linki | http://dx.doi.org/10.1002/slct.202103214 |
