| Yazarlar (4) |
Özcan Budak
Sakarya Üniversitesi, Türkiye |
|
Mehmet Sühha Bostancı
Sakarya Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Erdal KURTOĞLU
Erciyes University, Faculty Of Medicine, Türkiye |
|
Veysel Toprak
Tatvan Can Hospital, Türkiye |
| Özet |
| OBJECTIVE: This study evaluates the effects of a ketogenic diet on morphology and follicle reserve. METHOD: Sixteen Sprague-Dawley rats were randomized into two groups: standard diet group (n=8) and ketogenic diet group (n=8). Rats were time mated. Dams were permitted to deliver spontaneously. The animals were monitored for the onset of puberty. All the rats were weighed and anesthetized, serum anti-Müllerian hormone level was measured, and the oviducts were removed. The morphological characteristics of follicles were determined and total ovarian volumes were calculated. RESULTS: The mean ovarian volume was statistically significantly lower in the ketogenic diet group compared to the standard diet group (14.41±0.99 mm3 versus 18.89±1.28 mm3) (p=0.000). The mean number of antral follicles was 13.63±1.80 in the standard diet group and 4.462±0.760 in the ketogenic diet group. The mean ovarian weight of the ketogenic diet group was significantly lower than that of the standard diet group (0.42±0.06 g versus 0.815±107 g). The mean anti-Müllerian hormone levels were significantly higher in the standard diet group compared to the ketogenic diet group (1.023±4.75 ng/mL versus 0.69±0.07 ng/mL) (p=0.000). The mean percentage of staining of Ki-67 was 35.28±4.75 in the standard diet group and 16.98±3.33 in the ketogenic diet group (p=0.000). CONCLUSION: Maternal ketogenic diet reduces ovarian follicular reserve in female offspring and has important implications for maintaining reproductive potential at a population level. |
| Anahtar Kelimeler |
| Anti-Mullerian hormone | Ketogenic diet | Ovarian reserve | Reproduction |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Revista da Associação Médica Brasileira |
| Dergi ISSN | 0104-4230 Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q4 |
| Makale Dili | Türkçe |
| Basım Tarihi | 10-2021 |
| Cilt No | 67 |
| Sayı | 10 |
| Sayfalar | 1415 / 1420 |
| Doi Numarası | 10.1590/1806-9282.20210518 |
| Makale Linki | https://doi.org/10.1590/1806-9282.20210518 |
| Atıf Sayıları | |
| SCOPUS | 2 |
