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The potential protective effects of curcumin on the diabetic ovary: Experimental and molecular approaches     
Yazarlar (4)
Doç. Dr. Kıymet Kübra TÜFEKCİ Doç. Dr. Kıymet Kübra TÜFEKCİ
Kastamonu Üniversitesi, Türkiye
Gamze Altun
Maulilio John Kipanyula
Suleyman Kaplan
Devamını Göster
Özet
Diabetes mellitus (DM) causes numerous systemic diseases in animals and humans. This may also lead to reproductive problems among individuals of reproductive age. Detrimental effects such as apoptosis in ovarian granulosa cells, degradation of communication proteins, decreased oocyte quality, delayed meiotic maturation, and atrophy are among the increasing evidence that chronic hyperglycemia causes reproductive problems. Numerous studies have reported that the antidiabetic properties of the antioxidant curcumin may be due to its inhibition of oxidative stress, inflammation, and insulin resistance. There are also data indicating that curcumin reduces the risk of DM and its associated symptoms. This review discusses the protective or curative properties of curcumin in the treatment of DM-related problems in the ovary and seeks to elucidate potential underlying mechanisms. While the use of curcumin as a supportive/therapeutic agent has been introduced for the reduction of reproductive problems that may be caused by uncontrolled DM, more studies on this subject are needed.
Anahtar Kelimeler
Curcumin | Diabetes mellitus | Ovary | Female fertility
Makale Türü Diğer (Teknik, not, yorum, vaka takdimi, editöre mektup, özet, kitap krıtiği, araştırma notu, bilirkişi raporu ve benzeri)
Makale Alt Türü Uluslararası alan indekslerindeki dergilerde yayımlanan teknik not, editöre mektup, tartışma, vaka takdimi ve özet türünden makale
Dergi Adı HISTOLOGY AND HISTOPATHOLOGY
Dergi ISSN 0213-3911 Wos Dergi Scopus Dergi
Makale Dili İngilizce
Basım Tarihi 07-2025
Cilt No 40
Sayı 7
Sayfalar 947 / 966
Doi Numarası 10.14670/HH-18-866