| Yazarlar (9) |
Kemal Oncu
|
Dr. Öğr. Üyesi Yener YAZĞAN
|
|
Alpaslan Tanoglu
|
|
Mustafa Kaplan
|
|
Fatih Ermis
|
|
Osman Metin Ipcioglu
|
|
Muammer Kara
|
|
Irfan Kucuk
|
|
Halil Onur Ozari
|
| Özet |
| Familial Mediterranean fever (FMF), the most frequent periodic fever syndrome, is an autosomal recessive inherited disease that predominantly affects eastern Mediterranean populations. Fetuin-A is a well known negative acute-phase protein. Studies of this glycoprotein as a marker of inflammation in FMF are limited. We have investigated the relationship between serum levels of fetuin-A and inflammatory markers in patients with FMF before, during, and after FMF attacks. Sixty-seven patients with FMF were enrolled in this study. Serum fetuin-A, seruloplasmin, fibrinogen, C reactive protein (CRP), white blood cell count (WBC), calcium, and erythrocyte sedimentation rate (ESR) were measured three times: during the attack-free period, 12 h after FMF attacks, and 7 days after FMF attacks. Plasma fetuin-A concentration was measured by use of an enzyme-linked immunoassay (ELISA) kit. Correlations and differentiation between the serum fetuin-A and other inflammatory markers in patients with FMF were investigated by use of the paired-samples T test and the Pearson correlation test (p < 0.01). Serum fetuin-A levels of all FMF patients in the attack period were significantly lower than in the attack-free period (p < 0.001). In contrast, serum seruloplasmin (p < 0.05), fibrinogen (p < 0.001), CRP (p < 0.05), WBC (p < 0.05), and ESR (p < 0.05) were all significantly higher than in the attack-free period. Plasma fetuin-A is significantly and inversely highly correlated with the other inflammatory markers. Fetuin-A might be a novel indicator of disease activity in patients with FMF and could be used as an adjunctive marker for differentiation of FMF attacks. The negative correlation between serum fetuin-A and other inflammatory markers may also be indicative of inflammation-dependent downregulation of fetuin-A expression in FMF patients. |
| Anahtar Kelimeler |
| Familial Mediterranean fever | Inflammatory marker | Fetuin-A | Inflammation |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | ESCI dergilerinde yayınlanan tam makale |
| Dergi Adı | DIGESTIVE DISEASES AND SCIENCES |
| Dergi ISSN | 0163-2116 Wos Dergi Scopus Dergi |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2013 |
| Cilt No | 58 |
| Sayı | 11 |
| Sayfalar | 3212 / 3217 |
| Doi Numarası | 10.1007/s10620-013-2814-7 |
| Atıf Sayıları | |
| WoS | 14 |
