| Yazarlar |
Ozturk Fatma
|
|
Leyla Açık
Gazi Üniversitesi, Türkiye |
Prof. Dr. İzzet ŞENER
Pamukkale Üniversitesi, Türkiye |
|
Fikret Karcı
Pamukkale Üniversitesi, Türkiye |
|
Emine Kılıç
Ankara Üniversitesi, Türkiye |
| Özet |
| The purpose of the present study was to evaluate the antimicrobial effects of 3-hetarylazoquinoline-2,4- diols (19), having substituted or unsubstituted thiazole, benzothiazole, benzimidazole, triazole, isoxazole, and thiadiazole moieties at the 3-position, on bacterial and yeast strains. In addition, compounds and DNA interaction with pUC18 plasmid DNA were studied. The biological effects of these molecules were compared with potential antibiotics ampicillin, chloramfenicol (for bacteria), and ketoconozole (for yeast). According to the results, all compounds except 8 have mild to moderate activity against some of the bacterial strains tested, and none of the compounds have activity against the fungi C. tropicalis and C. albicans. Compounds 1 and 6 have moderate activities against B. cereus and B. subtilis, and compounds 5 and 6 have moderate activities and 1 has mild activity against E. coli. Compound 2 has a mild effect on all bacterial strains except E. coli ATCC 25922, P. vulgaris, and S. aureus. Compounds 3-5 and 7 have mild activity against some of the bacterial strains tested. Compound 9 has mild activity against all bacterial strains except E. coli ATCC 25922. Compound 8 has no antibacterial effect. Compounds and DNA interaction results indicate that as the compounds bind to DNA, unwinding of supercoiled form I DNA takes place to change it from the negatively supercoiled form I to the nicked form II and linear form III DNA. The following studies showed that, among the synthesized compounds, 3-9 seem to be promising candidates possessing DNA cleavage activities besides anti-microbial properties to serve as chemical nucleases and chemotherapeutic agents. © 2012 Tübitak. |
| Anahtar Kelimeler |
| Antimicrobial property | Azo dye | DNA interaction | Quinoline-2,4-diol |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | TURKISH JOURNAL OF CHEMISTRY |
| Dergi ISSN | 1300-0527 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 01-2012 |
| Cilt No | 36 |
| Sayı | 2 |
| Sayfalar | 293 / 302 |
| Doi Numarası | 10.3906/kim-1107-14 |
| Atıf Sayıları | |
| WoS | 14 |
| SCOPUS | 16 |
| TRDizin | 1 |
| Google Scholar | 22 |
| Google Scholar | 23 |
