Synthesis characterization and biological activities of 4 imino 3 arylazo 4H pyrimido 2 1 b 1 3 benzothiazole 2 oles
Yazarlar (4)
Selinay Erişkin
Pamukkale Üniversitesi, Türkiye
Pamukkale Üniversitesi, Türkiye
Prof. Dr. Nesrin ŞENER Pamukkale Üniversitesi, Türkiye
Prof. Dr. Serkan Yavuz Gazi Üniversitesi, Türkiye
Prof. Dr. İzzet ŞENER Pamukkale Üniversitesi, Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | Medicinal Chemistry Research | ||
| Dergi ISSN | 1054-2523 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | İngilizce | Basım Tarihi | 08-2014 |
| Kabul Tarihi | – | Yayınlanma Tarihi | 27-02-2014 |
| Cilt / Sayı / Sayfa | 23 / 8 / 3733–3743 | DOI | 10.1007/s00044-014-0962-8 |
| Makale Linki | http://link.springer.com/10.1007/s00044-014-0962-8 | ||
| UAK Araştırma Alanları |
Organik Kimya
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| Özet |
| 4-Imino-3,4-dihydro-2H-pyrimido[2,1-b][1,3]benzothiazole-2-one (3) was synthesized by the reaction of 2-aminobenzothiazole with ethyl cyanoacetate in solvent free conditions at 150 °C. A series of pyrimido benzothiazole-based azo dyes 4(a–m) were obtained by the coupling of carbocyclic amine-based diazonium chloride with compound (3). The synthesized dyes were purified and characterized by elemental analysis, FT-IR, 1H NMR, and high-resolution mass spectral data. The solvatochromic behaviors of dyes in various solvents were examined. All the azo dyes exhibited pronounced in vitro antibacterial activities against Gram-positive and Gram-negative bacteria, as well as fungi. The results revealed that most of the compounds exhibited good levels of antibacterial activity. Compounds 4d and 4h showed excellent levels of antimicrobial activity with MIC values of 8.25 μg/mL. |
| Anahtar Kelimeler |
| Antimicrobial activity | Azo dyes | Diazo-coupling reaction | Pyrimido benzothiazole | Solvatochromism |
| Atıf Sayıları | |
| Web of Science | 21 |
| Scopus | 23 |
| Google Scholar | 28 |