Antitumor effects of Dadas Cress (Lepidium sativum var. sativum) on Ehrlich Ascites tumor cells: an in vitro and in vivo study
Yazarlar (9)
Dr. Öğr. Üyesi Demet ÜNALMIŞ AYKAR Kastamonu Üniversitesi, Türkiye
Prof. Dr. Harun Ülger Türkiye
Prof. Dr. Züleyha Doğanyiğit Türkiye
Prof. Dr. Gökçe Şeker Karatoprak Türkiye
Prof. Dr. Dilek Pandır Türkiye
Dr. Öğr. Üyesi Sümeyye Uçar Türkiye
Doç. Dr. Emin Kaymak Türkiye
Dr. Öğr. Üyesi Aslı Okan Oflamaz Türkiye
Doç. Dr. Seher Yilmaz Türkiye
| Makale Türü | Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale) | ||
| Dergi Adı | JOURNAL OF MOLECULAR HISTOLOGY (Q4) | ||
| Dergi ISSN | 1567-2379 Wos Dergi Scopus Dergi | ||
| Dergi Tarandığı Indeksler | SCI-Expanded | ||
| Makale Dili | Türkçe | Basım Tarihi | 09-2025 |
| Cilt / Sayı / Sayfa | 56 / 5 / 307–0 | DOI | 10.1007/s10735-025-10575-4 |
| Makale Linki | https://doi.org/10.1007/s10735-025-10575-4 | ||
| UAK Araştırma Alanları |
Mimarlık, Planlama ve Tasarım
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| Özet |
| Garden cress (Lepidium sativum L.) is widely used in nutrition and traditional medicine for its bioactive properties. Studies show its seeds and leaves have anticancer, antimicrobial, and antidiabetic effects. This study investigated the antitumor potential of an extract from the leaves of Dadaş cress (Lepidium sativum var. sativum), a Turkish variety, against Ehrlich Ascites Tumor (EAT) cells. In the in vitro study, Dadaş cress extract (DCE) was tested at 25, 50, and 100 µg/mL concentrations to evaluate its antitumor activity. Caspase-3/7 activity was measured by fluorometric assay, mitochondrial membrane depolarization by JC-1 dye, and cell cycle by flow cytometry. The 50 µg/mL group had the highest apoptosis rate at 48 h; 100 µg/mL caused the most mitochondrial depolarization at 24 h. After 72 h, the 5-FU group had the highest G0/G1 phase cells, while the 25 µg/mL DCE group had the highest S phase cells. In vivo … |
| Anahtar Kelimeler |
| Antitumor effect | Apoptosis | EAT | Garden cress |
BM Sürdürülebilir Kalkınma Amaçları
| Atıf Sayıları | |
| Web of Science | 2 |
| Google Scholar | 2 |