| Yazarlar (9) |
Doç. Dr. Fatih UĞUR
Kastamonu Üniversitesi, Türkiye |
İbrahim Yılmaz
T.C. Sağlık Bakanlığı,, Türkiye |
|
Ersin Güner
Ankara Numune Education And Research Hospital |
|
Mehmet Albayrak
Istanbul Rumeli University, Türkiye |
Dr. Öğr. Üyesi Recep TAŞKİN
Kastamonu Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Nurtaç SARIKAŞ
Kastamonu Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Mehmet Akif BİLDİRİCİ
Kastamonu Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Ayşe Başak DELLALBAŞI
Kastamonu Üniversitesi, Türkiye |
Dr. Öğr. Üyesi Candemir ÖZCAN
Kastamonu Üniversitesi, Türkiye |
| Özet |
| BackgroundThis study evaluates the effects of exenatide (EXE), a glucagon-like peptide-1 (GLP-1) receptor agonist, on bone healing in rats using a single radius cortical defect model and histopathological, biochemical, and in silico methods.MethodsForty-two male Sprague–Dawley rats, excluding controls, were divided into 7 groups after receiving a standard radius defect. The serum levels of total protein (TP), calcium (Ca2+), phosphorus (P), alkaline phosphatase (ALP), osteocalcin (OC), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) in each specimen were measured. Radius samples were examined histopathologically using hematoxylin and eosin (H&E) and Masson’s trichrome staining. Molecular docking analyses were used to assess EXE interactions with the GLP-1 receptor and osteogenic transcription factors. Statistical significance was set at p < 0.05.ResultsChanges in the selected serum … |
| Anahtar Kelimeler |
| Bone regeneration | Exenatide | GLP-1 receptor agonist | Inflammatory cytokines | Molecular docking |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale |
| Dergi Adı | Journal of Orthopaedic Surgery and Research |
| Dergi ISSN | 1749-799X Wos Dergi Scopus Dergi |
| Dergi Tarandığı Indeksler | SCI-Expanded |
| Dergi Grubu | Q1 |
| Makale Dili | İngilizce |
| Basım Tarihi | 10-2025 |
| Cilt No | 20 |
| Sayı | 883 |
| Doi Numarası | 10.1186/s13018-025-06300-2 |
| Makale Linki | https://josr-online.biomedcentral.com/ |
| Atıf Sayıları |
