Synthesis and Characterization of Some New 1,3,4-thiadiazole Compounds Derived from 3,4-(Methylenedioxy)cinnamic Acid and their Antimicrobial Activities
Yazarlar (7)
Prof. Dr. Halit MUĞLU Kastamonu Üniversitesi, Türkiye
Prof. Dr. Mahmut GÜR Kastamonu Üniversitesi, Türkiye
Prof. Dr. Nesrin ŞENER Kastamonu Üniversitesi, Türkiye
Maesm Ahmed Mohamed Ben Hsin
Kastamonu Üniversitesi, Türkiye
Prof. Dr. Sevil Özkınalı Hitit Üniversitesi, Türkiye
Doç. Dr. Osman Emre ÖZKAN Kastamonu Üniversitesi, Türkiye
Prof. Dr. İzzet ŞENER Kastamonu Üniversitesi, Türkiye
Makale Türü Özgün Makale (SSCI, AHCI, SCI, SCI-Exp dergilerinde yayınlanan tam makale)
Dergi Adı Letters in Organic Chemistry (Q4)
Dergi ISSN 1570-1786 Wos Dergi Scopus Dergi
Dergi Tarandığı Indeksler SCI
Makale Dili İngilizce Basım Tarihi 08-2019
Kabul Tarihi 05-01-2019 Yayınlanma Tarihi 23-08-2019
Cilt / Sayı / Sayfa 16 / 10 / 825–836 DOI 10.2174/1570178616666190118153815
Makale Linki http://www.eurekaselect.com/169142/article
UAK Araştırma Alanları
Organik Kimya
Özet
Some new 1,3,4-thiadiazole compounds derived from 3,4-(methylenedioxy)cinnamic acid were synthesized in this study. Their structures were determined using UV-Vis, IR, 1H-NMR, and 13C-NMR spectroscopy. Moreover, the antibacterial activities of the new 1,3,4-thiadiazole derivatives were tested against Gram positive (Enterococcus durans, Bacillus subtilis, and Staphylococcus aureus) and gram negative (Salmonella typhimurium, Escherichia coli, Salmonella enteritidis, Salmonella infantis, Salmonella kentucky, Enterobacter aerogenes) bacteria using the disk diffusion method. Furthermore, their antifungal activity was tested against Candida albicans using the disk diffusion method. Some of the synthesized compounds (V, VII, XIII, and XIV) showed antibacterial activity against S. aureus. Also, one synthesized compound (VIII) showed antibacterial activity against E. coli, exhibiting 8 and 9 mm inhibition zones …
Anahtar Kelimeler
1,3,4-Thiadiazole | Antibacterial activities | Antimicrobial activity | Gram positive | Gram-negative bacteria | IR and NMR spectroscopy