| Yazarlar |
Doç. Dr. Halit MUĞLU
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. Nesrin ŞENER
Kastamonu Üniversitesi, Türkiye |
Hamza Ahmedmohammad Emsaed
|
|
Sevil Özkınalı
Hitit Üniversitesi, Türkiye |
Doç. Dr. Osman Emre ÖZKAN
Kastamonu Üniversitesi, Türkiye |
|
Prof. Dr. Mahmut GÜR
Kastamonu Üniversitesi, Türkiye |
| Özet |
| New 1,3,4-thiadiazole compounds were synthesized through the cyclization reaction of 4-phenoxybutyric acid and N-phenylthiosemicarbazide derivatives with phosphorous oxychloride. The structures of 1,3,4-thiadiazole compounds (I–XII) were clarified using spectroscopic methods such as FT-IR, 1H NMR, and 13C NMR. Moreover, their antibacterial activities were tested against gram negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, Escherichia coli) and gram positive bacteria (Staphylococcus aureus, Bacillus subtilis, Enterococcus durans) using a disk diffusion method. An antifungal activity experiment was further carried out against Candida albicans using the disk diffusion method. While these compounds presented antibacterial activity against S. aureus, they did not show antimicrobial activity against gram negative (E. coli, E. aerogenes, S. kentucky, S. enteritidis, S. typhimurium, S. infantis) and gram positive (B. subtilis) bacteria, and the fungi C. albicans. |
| Anahtar Kelimeler |
| 1,3,4-Thiadiazole | Antimicrobial activity | IR and NMR spectroscopies |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | JOURNAL OF MOLECULAR STRUCTURE |
| Dergi ISSN | 0022-2860 |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 12-2018 |
| Cilt No | 1174 |
| Sayı | 1 |
| Sayfalar | 151 / 159 |
| Doi Numarası | 10.1016/j.molstruc.2018.03.116 |
| Makale Linki | https://linkinghub.elsevier.com/retrieve/pii/S0022286018304137 |
| Atıf Sayıları | |
| WoS | 14 |
| SCOPUS | 16 |
| Google Scholar | 26 |
