| Yazarlar |
Doç. Dr. Mahmut GÜR
Kastamonu Üniversitesi, Türkiye |
Prof. Dr. Nesrin ŞENER
Kastamonu Üniversitesi, Türkiye |
Çiğdem Albayrak Kaştaş
Sinop Üniversitesi, Türkiye |
Doç. Dr. Osman Emre ÖZKAN
Kastamonu Üniversitesi, Türkiye |
Doç. Dr. Halit MUĞLU
Kastamonu Üniversitesi, Türkiye |
|
Magboule A M Elmaswari
|
| Özet |
| Through a cyclization reaction of 2-phenylbutyric acid with N-phenylthiosemicarbazide and POCl3, novel 1,3,4-thiadiazole derivatives were synthesized. Their structures were confirmed using IR, 1H NMR, and 13C NMR spectroscopies and elemental analysis. The antibacterial activities of the obtained 1,3,4-thiadiazole derivatives were tested against Gram-negative bacteria (Salmonella enteritidis, Salmonella typhimurium, Enterobacter aerogenes, Salmonella infantis, Salmonella kentucky, and Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis, and Enterococcus durans) using a disk diffusion method. Moreover, an antifungal activity experiment was performed against Candida albicans using the disk diffusion method. It was observed that the synthesized 1,3,4-thiadiazole derivatives exhibited effective antimicrobial activity against S. aureus, E. coli, and C. albicans. Based on these results, the 1,3,4-thiadiazole derivatives can be considered as a source of bioactive agents for pharmacological and medicinal applications. |
| Anahtar Kelimeler |
| Makale Türü | Özgün Makale |
| Makale Alt Türü | SSCI, AHCI, SCI, SCI-Exp dergilerinde yayımlanan tam makale |
| Dergi Adı | Journal of Heterocyclic Chemistry |
| Dergi ISSN | 0022-152X |
| Dergi Tarandığı Indeksler | SCI |
| Makale Dili | İngilizce |
| Basım Tarihi | 11-2017 |
| Cilt No | 54 |
| Sayı | 6 |
| Sayfalar | 3578 / 3590 |
| Doi Numarası | 10.1002/jhet.2984 |
| Makale Linki | http://doi.wiley.com/10.1002/jhet.2984 |
| Atıf Sayıları | |
| WoS | 11 |
| SCOPUS | 16 |
